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Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 breast cancer.
2003 DEC 4 - (NewsRx.com & NewsRx.net) -- Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 breast cancer.
"Reactive oxygen species (ROS) cause cell death and are associated with a variety of maladies, from trauma and infection to organ degeneration and cancer. Cells mount a complex response to oxidative damage that includes signaling from transmembrane receptors and intracellular kinases," scientists in the United States report.
"We have analyzed the response to oxidative damage in human breast cancer cells expressing the Hpr6.6 (human membrane progesterone receptor) protein. Although Hpr6.6 is related to a putative progesterone-binding protein, Hpr6.6 is widely expressed in epithelial tissues and shares close homology with a budding yeast damage response protein called Dap1p (damage response protein related to membrane progesterone receptor)," wrote R.A. Hand and colleagues, University of Kentucky Medical Center.
"We report here that the Hpr6.6 protein regulates the response to oxidative damage in breast cancer cells. Expression of Hpr6.6 in MCF-7 cells sensitized the cells to death following long-term/low dose or short-term/high dose treatment with hydrogen peroxide," the researchers wrote.
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Source: HighBeam Research, Hpr6.6 protein mediates cell death from oxidative damage in MCF-7...