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EZH2 is a marker of aggressive breast cancer.
2003 DEC 4 - (NewsRx.com & NewsRx.net) -- EZH2 is a marker of aggressive breast cancer. According to a study from the United States, "The Polycomb Group Protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive prostate cancer.
"Here we investigate the functional role of EZH2 in cancer cell invasion and breast cancer progression. EZH2 transcript and protein were consistently elevated in invasive breast carcinoma compared with normal breast epithelia," wrote C.G. Kleer and colleagues, University of Michigan School of Medicine.
"Tissue microarray analysis, which included 917 samples from 280 patients, demonstrated that EZH2 protein levels were strongly associated with breast cancer aggressiveness. Overexpression of EZH2 in immortalized human mammary epithelial cell lines promotes anchorage-independent growth and cell invasion," the researchers wrote.
The researchers concluded: "EZH2-mediated cell invasion required an intact SET domain ...
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