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Comparative transductions of breast cancer cells by three DNA viruses.
2003 DEC 4 - (NewsRx.com & NewsRx.net) -- Comparative transductions of breast cancer cells by three DNA viruses.
"Defining the ideal vectors to transduce breast cancer using viruses is currently under intense preclinical evaluation," investigators in France report.
"Our study constitutes the first direct comparison of the infection efficiencies of a human serotype 5 (Ad5), a canine serotype 2 (CAV-2) adenovirus, and a human serotype 2 adeno-associated virus (AAV-2) in breast cancer cells," wrote A. Lucas and colleagues, INSERM.
"We observed an excellent infection efficiency for Ad5 vector, whereas both CAV-2 and AAV-2 vectors lead to low infection of these cells. Real-time PCR, flow cytometry, and antibody blocking studies suggest that Ad5 and CAV-2 infection ability is not strictly dependent on coxsackie adenovirus receptor (CAR) or alpha(v) integrin levels," the researchers wrote.
"In conclusion, our data suggest that ...
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Source: HighBeam Research, Comparative transductions of breast cancer cells by three DNA viruses.