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Bone sialoprotein overexpression fosters cancer cell metastasis in study mice.
2003 DEC 4 - (NewsRx.com & NewsRx.net) -- Bone sialoprotein overexpression fosters cancer cell metastasis in study mice.
According to recent research from the United States, "bone sialoprotein (BSP) is a major non-collagenous protein found almost exclusively in bone and other mineralized tissues including enamel, dentin and cementum. Although a role for BSP in mineralization has been indicated, BSP also appears to function in patho-physiological processes, including the metastasis of breast and prostate cancer cells to bone. The purpose of this study was to determine the role of BSP in the homing of cancer cells and to provide insights into the role of BSP in physiological as well as pathological processes."
"We established cultures of MDA-231 breast cancer cells stably transfected with DNA constructs of pIRES2-EGFP (green fluorescent protein) expressing human BSP (hBSP) cDNA (231BSP) under a CMV promoter, or with an antisense sequence of hBSP cDNA (231BSPAS), or with an empty vector as a control (231EV)," wrote J.H. Zhang and colleagues, Tufts University, School of Dentistry and Medicine.
"These three cell groups were selected for neomycin resistance using G418 and analyzed by flow cytometry for GFP expression. The resultant cultured cells expressed different levels of hBSP as detected by RT-PCR and Western blot. Among the three, 231BSP expressed the highest levels of hBSP while 231BSPAS expressed the lowest."
"The capacity of the tumor cells to metastasize ...
- Bone sialoprotein-coated femoral implants subject to loosening.
- Newspaper article from: Biotech Week June 30, 2004 700+ words
...NewsRx.net) -- Bone sialoprotein (BSP)-coated femoral implants...the first time that BSP is osteoinductive when...are not affected by BSP coating or histological...Orthopaedic Research (Bone sialoprotein-coated femoral implants...
- Eur J Med Res: Implant surface coatings with bone sialoprotein, collagen, and...
- Newspaper article from: Dental Implantology Update Hilbig, H. Kirsten, M. Rupietta, R. April 1, 2007 700+ words
...role in implant success. Although bone sialoprotein (BSP) has been found to be osteoinductive...In this study, the support of BSP-, collagen-, and fibronectin...expression of bone turnover markers like BSP and osteocalcin as well as osteonectin...
- Research from University of Western Ontario provides new data on...
- Newspaper article from: Biotech Week August 27, 2008 700+ words
...on fibronectin and bone sialoprotein,' is newly published...fibronectin (FN) and bone sialoprotein (BSP). Chondrocyte adhesion...protrusiveness of FN and BSP," wrote K.S...on fibronectin and bone sialoprotein. American Journal...
- Research from University of Washington, Department of Chemical Engineering has...
- Newspaper article from: Blood Weekly August 7, 2008 700+ words
...hydroxyapatite with adsorbed bone sialoprotein, bone osteopontin...hydroxyapatite (HAP). Bone sialoprotein (BSP) and bone osteopontin...HAP with adsorbed BSP as compared to OPN...hydroxyapatite with adsorbed bone sialoprotein, bone osteopontin...
- Findings in bone research reported from Tianjin Medical University, Department...
- Newspaper article from: Blood Weekly September 10, 2009 700+ words
...of osteoblasts." "Bone sialoprotein (BSP) is a mineralized tissue...nicotine suppresses BSP transcription mediated...promoter of the rat BSP gene." Nakayama and...Nicotine suppresses bone sialoprotein gene expression. Journal...
- Reports from University of Leipzig describe recent advances in bone...
- Newspaper article from: Biotech Week September 3, 2008 700+ words
...report 'Effect of bone sialoprotein and collagen coating...this study compared bone sialoprotein (BSP) as a surface...osteonectin expression. BSP precoating of the...Surgery (Effect of bone sialoprotein and collagen coating...
- New enzyme research findings from Johns Hopkins University, Medical Department...
- Newspaper article from: Biotech Week August 27, 2008 700+ words
"Bone sialoprotein (BSP) is a secreted glycophosphoprotein...formation by cells expressing BSP could be inhibited by...researchers concluded: "BSP modulation of MMP-2...study in Biochemistry (Bone sialoprotein binding to matrix metalloproteinase...
- Studies from University of Toronto update current data on cancer.
- Newspaper article from: Cancer Weekly July 28, 2009 700+ words
...the SIBLING protein bone sialoprotein (BSP) and MMP-2 leads...substratum showed that the BSP-alpha v beta 3 integrin...not support a role for BSP in promoting metastasis...study in BMC Cancer (Bone sialoprotein does not interact with...
