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Simulated weightlessness changes bone characteristics in male and female rats.
2003 DEC 4 - (NewsRx.com & NewsRx.net) -- Simulated weightlessness changes bone characteristics in male and female rats.
According to recent research from the United States, "prolonged spaceflight results in bone loss in astronauts, but there is considerable individual variation. The goal of this rat study was to determine whether gender influences bone loss during simulated weightlessness. Six-month-old Fisher 344 rats were hindlimb unweighted for 2 weeks (wk), after which the proximal tibiae were evaluated by histomorphometry."
"There were gender differences in tibia length, bone area, cancellous bone architecture, and bone formation. Compared with female rats, male rats had an 11.6% longer tibiae, a 27.8% greater cortical bone area, and a 37.6% greater trabecular separation. Conversely, female rats had greater cortical (316%) and cancellous (145%) bone formation rates, 28.6% more cancellous bone, and 30% greater trabecular number," noted T.E. Hefferan and colleagues, Mayo Clinic and Mayo Foundation, Department of Orthopedics.
"Hindlimb unweighting resulted in large reductions in periosteal bone formation and mineral apposition rate in both genders. Unweighting also caused cancellous bone loss in both genders; trabecular number was decreased, and trabecular ...
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Source: HighBeam Research, Simulated weightlessness changes bone characteristics in male and...