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Oral immunization with Giardia duodenalis protein inhibits shedding of cysts.
2003 DEC 3 - (NewsRx.com & NewsRx.net) -- Oral immunization of BALB/c mice with Giardia duodenalis recombinant cyst wall protein inhibited the shedding of cysts.
"The process of encystation is a key step in the Giardia duodenalis life cycle that allows this intestinal protozoan to survive between hosts during person-to-person, animal-to-person, waterborne, or food-borne transmission. The release of cysts from infected persons and animals is the main contributing factor to contamination of the environment. Genes coding for cyst wall proteins (CWPs), which could be used for developing a transmission-blocking vaccine, have been cloned," researchers in Canada report.
"Since the immunogenicity of recombinant Giardia CWP is unknown, we have investigated the immunogenicity of recombinant CWP2 (rCWP2) and its efficacy in interfering with the phenomenon of encystation taking place in the small bowels of BALB/c mice vaccinated with the recombinant protein," stated R. Larocque and colleagues at McGill University. "Here we report that the immunization of BALB/c mice with rCWP2 stimulated the immune system in a manner comparable to that for a live infection with Giardia muris cysts. Fecal and serum anti-rCWP2 immunoglobulin A (IgA) antibodies were detected in the immunized mice. In addition, anti-rCWP2 IgG1 and IgG2a ...
- Oral immunization with Giardia duodenalis protein inhibits shedding of cysts.
- Newspaper article from: Immunotherapy Weekly December 3, 2003 700+ words
...key step in the Giardia duodenalis life cycle that...and colleagues at McGill University. "Here we report...BALB/c mice with Giardia duodenalis recombinant cyst...Gaetan M. Faubert, McGill University, Institute of...
- Novel assay useful for Giardia duodenalis detection.(Brief Article)
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- Newspaper article from: Health & Medicine Week October 6, 2003 700+ words
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- Novel assay useful for Giardia duodenalis detection.
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