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Mucosal immunization with DNA vaccines reviewed.

Vaccine Weekly

| December 03, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers review mucosal immunization with DNA vaccines in a recent issue of the journal Methods.

According to a study from England, "DNA vaccines represent a new approach to the control of infectious disease. Both cellular and humoral immune responses are induced without the attendant concerns associated with live, attenuated vaccines. The vast majority of DNA vaccines are delivered by parental routes, which rarely elicit immune responses at the mucosal epithelia, the primary sites of pathogen transmission."

"In view of the importance of mucosal and regional lymph node immunity in the control of pathogens transmitted across the mucosal epithelia, a number of groups, including our own, have developed immunization strategies that target plasmid DNA to mucosal inductive sites associated with the lymphoid tissues of the respiratory, gastrointestinal, and genital tracts," said Philip Hobson and colleagues at Guy's, King's and St. Thomas' School of Medicine in London. ...

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