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Heat shock protein-mediated antigen targeting increases DNA vaccine potency.
2003 DEC 3 - (NewsRx.com & NewsRx.net) -- Secretory heat shock protein-mediated antigen targeting increases DNA vaccine potency.
"In an effort to enhance the potency of DNA vaccines, we have developed a new strategy to increase antigen presentation by dendritic cells, one that results in markedly improved cytotoxic T-lymphocyte responses, antibody production, and antitumor effects in vivo. Here, we present the rationale and design of a vaccine encoding a secreted antigen-heat shock protein 70 fusion molecule, targeted to the MHC class 1 cross-presentation pathway of dendritic cells," scientists in Austria and the United States report.
"Using the human papillomavirus 16 E7 protein as a model antigen, we illustrate the preparation of this vaccine and the main experimental procedures used to test such constructs," said Hanns Hauser at the University of Vienna in Austria and Si-Yi Chen at Baylor ...
- DNA vaccine inhibits autoimmune disease in rat model.
- Newspaper article from: Gene Therapy Weekly December 5, 2002 700+ words
...the mycobacterial 65-kDa heat shock protein (HSP65). HSP65...with the mammalian 60-kDa heat shock protein (HSP60) are thought...of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J Immunol, 2002...
- DNA vaccine induces protection against intracellular bacterial pathogen.
- Newspaper article from: Proteomics Weekly May 31, 2004 700+ words
...Effective vaccination using in vitro peptide-loaded heat-shock proteins (HSP), tumor-derived HSP, and HSP fusion proteins...comes under the major subject areas of Listeria Vaccine, DNA Vaccine, Bacteriology, Cancer Vaccine, Oncology, Proteomics...
- Heat-shock protein as dendritic cell target enhances vaccine potency.
- Newspaper article from: Biotech Week July 28, 2004 700+ words
...Using secretory heat-shock protein as a dendritic...utilized in the DNA vaccine setting since...to DCs by a heat-shock protein (HSP...Therapy (Secretory heat-shock protein as a dendritic...subject areas of DNA Vaccine, Cancer Vaccine...
- Powderject DNA vaccine achieves protective immunity.(Brief Article)
- Newspaper article from: BIOTECH Patent News April 1, 2001 700+ words
...achievement of protective immunity by a DNA vaccine in volunteers who do not respond to...preliminary data from the hepatitis B DNA vaccine clinical study will be presented at...study is part of PowderJect's major DNA vaccine collaboration with GlaxoSmithKline...
- PowderJect DNA Vaccine First to Achieve Protective Immunity in Non-Responders...
- Press release article from: PR Newswire April 24, 2001 700+ words
...achievement of protective immunity by a DNA vaccine in volunteers who do not respond to...preliminary data from the hepatitis B DNA vaccine clinical study will be presented today...study is part of PowderJect's major DNA vaccine collaboration with GlaxoSmithKline...
- Vical Introduces RapidResponse(TM) DNA Vaccine Cell-Free Platform Designed to...
- Press release article from: PR Newswire June 4, 2007 700+ words
...today announced the RapidResponse(TM) DNA vaccine platform designed to produce large quantities...of Vical. "The RapidResponse(TM) DNA vaccine platform has the potential to develop...genetic sequence." RapidResponse(TM) DNA vaccine manufacturing involves a cell-free...
- DNA vaccine protected chimps from AIDS virus, scientists say.(Originated from...
- Newspaper article from: Knight Ridder/Tribune News Service Collins, Huntly Shaw, Donna April 29, 1997 700+ words
...infection with the AIDS virus. The DNA vaccine is made with the genetic material of...are the first to demonstrate that a DNA vaccine can confer protection against HIV in...achieve protection in chimps with a DNA vaccine,'' said William Paul, an immunologist...
- Vical Advances RapidResponse(TM) DNA Vaccine Platform Under $6 Million Grant...
- Press release article from: PR Newswire June 25, 2008 700+ words
...advancing with the development of a DNA vaccine manufacturing process with the potential...Platform The RapidResponse(TM) DNA vaccine manufacturing platform is intended to...dedicated facilities. RapidResponse(TM) DNA vaccine manufacturing involves a cell-free...
- Vical's DNA Vaccine Provides Complete Protection Against Avian Influenza and...
- Press release article from: PR Newswire May 2, 2006 700+ words
...three-component influenza (flu) DNA vaccine candidate provided 100 protection in...the company's program to develop a DNA vaccine that protects humans against emerging...toward human testing of the pandemic flu DNA vaccine candidate. "We are encouraged by the...
- Vical Receives $6 Million Grant From NIH to Advance RapidResponse(TM) DNA...
- Press release article from: PR Newswire June 12, 2007 700+ words
...NIH), for further development of a DNA vaccine manufacturing process with the potential...Platform The RapidResponse(TM) DNA vaccine manufacturing platform is intended to...dedicated facilities. RapidResponse(TM) DNA vaccine manufacturing involves a cell-free...
Source: HighBeam Research, Heat shock protein-mediated antigen targeting increases DNA vaccine...