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2003 DEC 3 - (NewsRx.com & NewsRx.net) -- Scientists have published a list of candidates for immune modulation and immunization regimens using DNA vaccines in a recent issue of Methods.
According to recent research from the United States, "DNA vaccine strategies can differ greatly, with significant effects on the outcome of immunization. In this article, we discuss plasmid design strategies and vaccine regimens."
"Effectiveness against a pathogen can be affected by the choice of antigen and inclusion of multiple antigens," said Nicole A. Doria-Rose and Nancy L. Haigwood at the University of Washington in Seattle. "Gene expression and the resulting immune response can be improved by gene modification and choice of promoters. In designing vaccine regimens, one must consider further dose, timing of doses, adjuvants, and routes of vaccination."
"Many vaccines are enhanced by combining DNA with other vaccines in 'prime-boost' regimens, in which the second vaccine is often a recombinant viral vector or purified protein subunit," stated Doria-Rose and Haigwood. ...
Source: HighBeam Research, Candidates for immunization regimens using DNA vaccines described.