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Natural antibodies and complement are endogenous adjuvants for vaccines.
2003 DEC 3 - (NewsRx.com & NewsRx.net) -- Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses.
"CD8+ T cells are essential for long-term, vaccine-induced resistance against intracellular pathogens. Here we show that natural antibodies, acting in concert with complement, are endogenous adjuvants for the generation of protective CD8+ T cells after vaccination against visceral leishmaniasis. IL-4 was crucial for the priming of vaccine-specific CD8+ T cells, and we defined the primary source of IL-4 as a CD11b+CD11c[superscript]lo phagocyte," investigators in England report.
"IL-4 secretion was not observed in antibody-deficient mice and could be reconstituted with serum from normal, but not Btk immune-deficient, mice," stated Simona Stager at the London School of Hygiene and Tropical Medicine and collaborators in the U.K., the Netherlands, and South Africa. "Similarly, no IL-4 response or CD8+ T-cell priming was seen in C1qa[superscript]-/- mice. These results identify a new pathway by ...
- BioTransplant Collaborators at MGH Report Advances Toward Establishing...
- Press release article from: PR Newswire September 18, 1998 700+ words
...xenografted porcine tissue is caused by natural antibodies, the majority of which are directed...including eliminating the circulating natural antibodies, these antibodies eventually return...gene therapy, the production of natural antibodies in a murine [mouse] model. This...
- Massachusetts General Hospital and BioTransplant Report Research Advances for...
- Press release article from: PR Newswire October 25, 1999 700+ words
...to be sensitive to rejection via natural antibodies, and when transplanted into a primate...least half of the pig-specific natural antibodies in primates. The researchers investigated...or prevent the appearance of these natural antibodies and to promote tolerance to pig xenografts...
- Immunomedics Developing Vaccines for Cancer and Infectious Diseases.
- Press release article from: PR Newswire February 2, 2000 700+ words
...galactose bind to their targets and "coat" them with this receptor for the natural antibodies. "Humans and certain lower primates have these natural antibodies without the alpha-galactose antigen in their systems," explained Dr. Goldenberg...
- The xeno-solution. (animal-to-human organ transplants)(includes related article)
- Magazine article from: Science News Travis, John November 4, 1995 700+ words
...human blood, as well as that of many nonhuman primates, are natural antibodies that view alpha-gal molecules as evidence of a foreign invasion. "The xenoreactive natural antibodies, as soon as blood flows into that organ, will recognize...
- Scientists at Stanford University, Medical Department target Alzheimer disease.
- Newspaper article from: Biotech Business Week September 21, 2009 700+ words
...we demonstrate with peptide microarrays the presence of natural antibodies against known toxic A beta and amyloidogenic non-A beta...Sciences of the United States of America (Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with...
- Research data from Wageningen University update understanding of poultry...
- Newspaper article from: Agriculture Week September 17, 2009 700+ words
...disease and infectious bursal disease vaccines; levels of natural antibodies binding lipopolysaccharide, lipoteichoic acid, and keyhole...significant differences were found in lipoteichoic acid natural antibodies of the control and low line hens. At the end of the observation...
- RESEARCHERS PROGRESS ON COCAINE VACCINE.(CAPITAL REGION)
- Newspaper article from: Albany Times Union (Albany, NY) April 3, 1995 700+ words
...counterparts of the ``smart bombs'' used in the gulf war. Natural antibodies are proteins, made by the immune system, that help the...circulating in the blood. They attach to cocaine, just like natural antibodies attach to disease-causing bacteria. Then they act as...
- Data from Karolinska University advance knowledge in life sciences.
- Magazine article from: Women's Health Weekly September 11, 2008 700+ words
...from Huddinge, Sweden, "We have recently reported that natural antibodies against phosphorylcholine (anti-PC) have atheroprotective...and colleagues published their study in Rheumatology (Natural antibodies against phosphorylcholine as potential protective factors...
Source: HighBeam Research, Natural antibodies and complement are endogenous adjuvants for...