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Protective effect of 6746 SERA peptide against malaria linked to alpha helix.
2003 DEC 3 - (NewsRx.com & NewsRx.net) -- The protective effect of 6746 SERA peptide analogues against malaria is associated with short alpha helix formation.
"Erythrocyte high activity binding peptides (HABPs) have been identified for the Plasmodium falciparum serine repeat antigen (SERA). HABP 6746, located in this protein's 50-kDa fragment had its critical binding residues replaced by amino acids having similar mass but different charge to change their immunologic properties. This peptide analogues were used to immunize Aotus monkeys that were challenged later on with a virulent P. falciparum strain to determine their protective efficacy," researchers in Colombia report.
"A shortening in alpha helix structure was found in the immunogenic and protective ones when their secondary structure was analyzed by NMR, to correlate their structure with their immunologic properties," said Martha Patricia Alba and collaborators at the Fundacion Instituto de Inmunologia de Colombia (FIDIC) and Universidad Nacional de Colombia. "These data, together with results from previous studies, suggest that this shortening in HABP helical ...
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...other gasoline additives. Words to Know Alpha helix: A type of secondary structure in which...common of these structures is known as an alpha helix. Think of what a Slinky ™...of those structures is similar to an alpha helix. Many protein molecules have a similar...
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Source: HighBeam Research, Protective effect of 6746 SERA peptide against malaria linked to...