AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Attenuated FIV vaccine protects against systemic or mucosal challenge.
2003 DEC 3 - (NewsRx.com & NewsRx.net) -- An attenuated FIV vaccine provided protection from an intraclade challenge administered systemically or mucosally.
"Feline immunodeficiency virus (FM) infection of domestic cats represents a valuable system through which to investigate criteria for antilentiviral vaccines in a natural host species. Here, we examined whether vaccination with a strain of FIV attenuated as a result of prolonged growth in vitro could protect against a fully virulent, highly heterologous intraclade challenge," investigators in Italy report.
"The results indicated that the vaccine virus produced a low-grade infection with no detectable pathological effects and afforded a long-lasting sterilizing immunity if the challenge was delivered intraperitoneally as cell-free virus but not against a cell-associated intravaginal challenge," said Mauro Pistello and colleagues at the University of Pisa. "In the latter case, however, the replication and pathological consequences of the challenge virus were markedly suppressed."
The researchers concluded, "Together with similar results obtained in rhesus monkey models, these findings ...
- Attenuated FIV vaccine protects against systemic or mucosal challenge.
- Newspaper article from: Drug Week December 5, 2003 700+ words
...An attenuated FIV vaccine provided...protection from an intraclade challenge administered...heterologous intraclade challenge," investigators...development of attenuated FIV vaccines...Protection from an intraclade challenge administered...
