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Tumoral immune resistance based on tryptophan degradation by enzyme.
2003 DEC 3 - (NewsRx.com & NewsRx.net) -- Researchers have found evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase.
According to a study from Belgium, "T lymphocytes undergo proliferation arrest when exposed to tryptophan shortage, which can be provoked by indoleamine 2,3-dioxygenase (IDO), an enzyme that is expressed in placenta and catalyzes tryptophan degradation. Here we show that most human tumors constitutively express IDO. We also observed that expression of IDO by immunogenic mouse tumor cells prevents their rejection by pre-immunized mice."
"This effect is accompanied by a lack of accumulation of specific T cells at the tumor site and can be partly reverted by systemic treatment of mice with an inhibitor of IDO, in the absence of noticeable toxicity," said Catherine Uyttenhove and colleagues at the Universite de Louvain. "These results suggest that the efficacy of ...
- Hyperactive immune resistance brings blindness in old age.
- Newspaper article from: Biotech Week August 6, 2008 700+ words
...demonstrated that in cases of senile blindness the patient's immune resistance is hyperactive throughout his entire body (see also University...This system is an important element in our hereditary immune resistance, and is involved where inflammatory reactions occur...
- SUPPORT YOUR IMMUNE RESISTANCE.
- Magazine article from: Health Products Business April 1, 2000 700+ words
...from cultivated herbs. This combination of two of the most widely used North American winter botanicals is formulated to support immune resistance. The extract is available in 1-fl. oz., 2-fl. oz. and 4-fl. oz. bottles.
- Scientists overcome immune resistance in dendritic cell vaccines for cancer.
- Newspaper article from: Cancer Vaccine Week April 26, 2004 700+ words
2004 APR 26 - (NewsRx.com & NewsRx.net) -- Scientists have discovered why dendritic cell vaccines do not attack cancer as forcefully as expected, and they have demonstrated how to overcome this constraint by bolstering the vaccines' tumor-seeking machinery. The findings, published in the April
- New enzyme research study findings have been reported by scientists at...
- Newspaper article from: Biotech Week June 10, 2009 700+ words
...study was to investigate whether tryptophan degradation is associated with outcome in patients...These results imply that increased tryptophan degradation in patients is due to activated...their study in Clinical Science (Tryptophan degradation in multiple trauma patients: ...
- New psychiatric disorders research from Barry University described.(Report)
- Newspaper article from: Biotech Week July 1, 2009 700+ words
...kynurenine pathway of tryptophan degradation may serve to integrate...concluded: "Increased tryptophan degradation in psychoses may have...evidence of increased tryptophan degradation. Journal of Psychopharmacology...
- Studies from University College describe new findings in irritable bowel...
- Newspaper article from: Biotech Week April 29, 2009 700+ words
...disorders. The kynurenine pathway of tryptophan degradation may serve to link these findings...In this study, we investigated tryptophan degradation in a male IBS cohort (n = 10...study in BMC Gastroenterology (Tryptophan degradation in irritable bowel syndrome: evidence...
- Extracts of pumpkin (Cucurbita pepo L.) seeds suppress stimulated peripheral...
- Magazine article from: American Journal of Immunology Winkler, Christiana Wirleitner, Barbara Schroecksnadel, Katharaina Schennach, Harald Fuchs, Dietmar January 1, 2005 700+ words
...phytohaemagglutinin and concanavalin A in vitro. Tryptophan degradation and neopterin concentrations were...induced neopterin production and tryptophan degradation in a dose-dependent way. Data...compounds on immunocompetent cells. Tryptophan degradation and neopterin formation are ...
- APC-expressed indoleamine 2,3-dioxygenase degrades tryptophan; lowers atopy.
- Newspaper article from: Biotech Week January 21, 2004 700+ words
...Indoleamine 2,3-dioxygenase is expressed by APC; tryptophan degradation may help induce tolerance in atopy. According to published...researchers concluded: "We introduce the hypothesis that tryptophan degradation might add to the ability to control and downregulate...
- Uncaria tomentosa extracts have potential application as immunomodulator.
- Newspaper article from: Blood Weekly June 10, 2004 700+ words
...scientists in Austria report. "Neopterin production and tryptophan degradation were monitored in culture supernatants to determine...suppression of mitogen-induced neopterin production and tryptophan degradation was observed," said Winkler. Investigators concluded...
- International Specialty Products (ISP): a leader in specialty chemicals for...
- Magazine article from: Drug & Cosmetic Industry June 1, 1997 700+ words
...for example, the company launched Escalol [R] HP-610, a unique hair protectant designed to minimize tryptophan degradation and disulfide bond cleavage, resulting in smoother, healthier hair. A cationic material, it remains on...
Source: HighBeam Research, Tumoral immune resistance based on tryptophan degradation by enzyme.