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Oral delivery of Norwalk virus-like particles elicits IgA antibodies.
2003 NOV 19 - (NewsRx.com & NewsRx.net) -- Oral vaccination with Norwalk virus-like particles elicited the production of IgA antibodies in volunteers.
According to published research from the United States, "Norwalk virus-like particles (VLPs), made from recombinant capsid protein, are a promising vaccine. Thirty-six healthy adult volunteers received 250 micrograms (n=10), 500 micrograms (n=10), or 2,000 micrograms (n=10) of orally administered VLP or placebo (n=6)."
"All vaccinees developed significant rises in IgA anti-VLP antibody-secreting cells," reported Carol O. Tacket and collaborators at the University of Maryland and Baylor College of Medicine. "Ninety percent who received 250 micrograms developed rises in serum anti-VLP IgG; neither the rates of seroconversion nor geometric mean titers increased at the higher doses. About 30-40% of volunteers developed mucosal anti-VLP IgA. Lymphoproliferative responses and IFN-gamma production were observed transiently among ...
- Oral delivery of Norwalk virus-like particles elicits IgA antibodies.
- Newspaper article from: Proteomics Weekly November 17, 2003 700+ words
...immune responses to oral Norwalk virus-like particles in volunteers...O. Tacket, Center for Vaccine Development, University of Maryland...major subject areas of Norwalk Virus Vaccine, Vaccine Development, Immunotherapy, Mucosal...
- VIRUS INTERLOPES INTO BACTERIAL DIARRHEA SCENE EDIBLE NORWALK VIRUS VACCINE -...
- Magazine article from: BIOWORLD Today Leff, David N. June 28, 2000 700+ words
...wreaking prowess. The Norwalk virus' name goes back...human vaccine against Norwalk virus infection. Last...Medicine's Center for Vaccine Development, in Baltimore...come to create the Norwalk virus vaccine, and that...
- The Norwalk Virus: A Guidance Template for Local Environmental Health...
- Magazine article from: Journal of Environmental Health Eddy, Christopher Ingram, Timothy Leever, Jeffery September 1, 2000 700+ words
...group in this paper under the rubric "Norwalk virus." The Hamilton County Health District...disease outbreaks associated with the Norwalk virus over a three-year period from April...the lessons learned from confirmed Norwalk virus outbreaks and provide insight into...
- A Food Safety Primer: The Risky Nature of the Norwalk Virus.(shellfish cookery...
- Magazine article from: Consumers' Research Magazine Hunter, Beatrice Trum July 1, 2001 700+ words
...epidemic viral gastroenteritis (such as Norwalk virus, rotavirus, and hepatitis A) involves...Hence, the pathogen was named the Norwalk virus. Other viruses have been named to...producing the viruses themselves. The Norwalk virus and the Norwalk-like virus (a related...
- Norwalk Virus Killed With World's First Safe Disinfectant; Scientific...
- Press release article from: PR Newswire February 19, 2003 700+ words
...achieved a kill as high as 99.99% of the Norwalk virus simulant (FCV). The Norwalk virus causes intestinal discomfort and illness...create a safe and effective solution to Norwalk virus outbreaks," said Diana Hoffman, EnviroSystems...
- Corticosteroids/tacrolimus: Norwalk virus enteritis (first report with...
- Magazine article from: Reactions Weekly Anonymous June 21, 2008 700+ words
Two infants developed Norwalk virus enteritis while under immunosuppression...his stools tested positive for Norwalk virus during each episode. His corticosteroid...increased to 70-80 mL/kg/day. Norwalk virus was detected in his stool [duration...
- Norwalk virus shedding after experimental human infection.(RESEARCH)(Clinical...
- Magazine article from: Emerging Infectious Diseases Atmar, Robert L. Opekun, Antone R. Gilger, Mark A. Estes, Mary K. Crawford, Sue E. Neill, Frederick H. Graham, David Y. October 1, 2008 700+ words
...had been experimentally infected with Norwalk virus. Of 16 persons, clinical gastroenteritis...studies of naturally acquired infection. Norwalk virus is the prototype strain in the genus...virus shedding in persons infected with Norwalk virus after experimental inoculation. ...
- Norwalk virus--specific binding to oyster digestive...
- Magazine article from: Emerging Infectious Diseases Le Guyader, Francoise S. Loisy, Fabienne Atmar, Robert L. Hutson, Anne M. Estes, Mary K. Ruvoen-Clouet, Nathalie Pommepuy, Monique Le Pendu, Jacques June 1, 2006 700+ words
...concentration. We investigated whether Norwalk virus or viruslike particles bind specifically...determined the fate of prototype genogroup I Norwalk virus particles in bioaccumulation experiments...17,18). Materials and Methods Norwalk Virus Strain and Recombinant Viruslike ...