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Transgenic plants express human papillomavirus type 16 major capsid protein.
2003 NOV 19 - (NewsRx.com & NewsRx.net) -- Scientists have developed transgenic plants that express human papillomavirus type 16 major capsid protein.
According to published research from South Africa, "The production of vaccine antigens in plants is a safe and potentially very cost-effective alternative to traditional expression systems. We investigated the possibility of transgenic plant expression of the human papillomavirus (HPV) type 16 L1 major capsid protein, with and without nuclear localization signals, in Nicotiana tabacum cv. Xanthi plants."
"The genes were stably integrated into the N. tabacum genome, and both the expressed proteins were capable of assembling into capsomers and virus-like particles," reported "The proteins in concentrated leaf extracts (L1[subscript]Tr) were tested for antigenicity using a panel of characterized monoclonal antibodies (Mabs). Neutralizing and conformation-specific Mabs (H16:V5 and H16:E70) were shown to bind to both types of the plant-produced particles. We estimated the L1[subscript]Tr product yield to be 2-4 micrograms ...
- Data on human papillomavirus described by researchers at INSERM.(Report)
- Magazine article from: Women's Health Weekly September 17, 2009 700+ words
...epitopes of the major capsid protein of human papillomavirus type 31. Analysis...epitopes on the human papillomavirus type 31 major capsid protein and functional...Genomics, HPV, Human Papillomavirus, Peptide, Proteins...
- Data from P. Lenzi and colleagues advance knowledge in human...
- Newspaper article from: Cancer Vaccine Week December 29, 2008 700+ words
...Transgenic Research, "Human Papillomavirus (HPV) is the...for women. The major capsid L1 protein self...colleagues (see also Human Papillomavirus). The researchers...chloroplast-expressed human papillomavirus type 16 L1 capsid...
- Research reports on human papillomavirus from University of Colorado, Medical...
- Magazine article from: Women's Health Weekly December 25, 2008 700+ words
...72 capsomeres of their major capsid proteins, VP1 and L1...States report (see also Human Papillomavirus). "Virion assembly...polyomavirus (mPy) VP1 and human papillomavirus type 11 (HPV11) L1 capsomeres...States, Aurora, HPV, Human Papillomavirus, Polyomavirus, ...
- Research from Medical University of Vienna in the area of human papillomavirus...
- Newspaper article from: Cancer Vaccine Week March 9, 2009 700+ words
...association of cutaneous human papillomavirus (HPV) types...assembled L1, the major capsid protein, has...Vienna (see also Human Papillomavirus). The researchers...between cutaneous human papillomavirus types 5, 8 and...
- Research by S. Brandt and colleagues in human papillomavirus provides new...
- Magazine article from: Women's Health Weekly August 21, 2008 700+ words
...Austria report (see also Human Papillomavirus). "To reassess this issue...DNA in a complex with L1 major capsid protein. Virology, 2008...Genetics, Genomics, HPV, Human Papillomavirus, Virology. This article...
- Human papillomavirus and cervical cancer.(Conference Session Summaries (1))
- Magazine article from: Emerging Infectious Diseases Unger, Elizabeth R. Barr, Eliav November 1, 2004 700+ words
...disease. Vaccine candidates have been evaluated in animal models of papillomavirus infection. The L1 protein of HPV is the major capsid protein and self-assembles into viruslike particles (VLPs). Species-specific VLP vaccines provide protection against...
- Human papillomavirus vaccine recombinant quadrivalent: First report of...
- Magazine article from: Reactions Weekly Anonymous October 11, 2008 700+ words
...receiving recombinant quadrivalent human papillomavirus vaccine [Gardasil]. The woman...doses of IM recombinant quadrivalent human papillomavirus vaccine [dosage not stated] into...her first recombinant quadrivalent human papillomavirus vaccine dose. Physical examination...
- New human papillomavirus study findings reported from E.Q. Wu and co-authors.
- Newspaper article from: Cancer Weekly September 1, 2009 700+ words
...Journal of Gynecological Cancer, "Human papillomavirus (HPV) is the main etiologic factor...in HSIL, and 63.4% in LSIL. Human papillomavirus 16 was the most predominant HPV...of HSIL, and 33.8% of LSIL. Human papillomavirus 45 was the second most predominant...
