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Human T-cells recognize N-terminally Fmoc-modified peptide.
2003 NOV 12 - (NewsRx.com & NewsRx.net) -- Human T-cells recognize N-terminally Fmoc-modified peptide.
According to a study from Australia, "We aimed to generate T-cell clones specific for human pre-proinsulin. An HLA DQ8, CD4+ T-cell clone that recognized a 10mer (C65-A9) peptide from pre-proinsulin was isolated. Further analysis revealed that the clone responded neither to recombinant proinsulin nor to re-synthesized C65-A9 peptide."
"Analysis of the original peptide revealed minor contamination (
Mannering and his coauthors published the results of their research in Vaccine (Human T-cells recognize N-terminally Fmoc-modified peptide. Vaccine, 2003;21(25-26):3638-3646).
For additional information, contact Stuart I. Mannering, Autoimmunity and Transplantation Division, The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, 1G Royal Parade, Parkville, Vic. 3050, ...
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Source: HighBeam Research, Human T-cells recognize N-terminally Fmoc-modified peptide.