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Mucosal delivery of HIV-1 Tat protein elicits strong immune response.
2003 NOV 12 - (NewsRx.com & NewsRx.net) -- Mucosal delivery of the human immunodeficiency virus-1 Tat protein in mice elicits systemic neutralizing antibodies, cytotoxic T lymphocytes, and mucosal IgA
According to a study from Italy, "Human immunodeficiency virus (HIV)-1 Tat protein induces protection in non-human primates upon systemic vaccination. In view of the design of mucosal vaccines against HIV-1 we studied the immune response to native Tat (aa 1-86) in mice following intranasal delivery of the protein with two mucosal adjuvants, Escherichia coli heat-labile enterotoxin (LT) and LT-R72, a non-toxic mutant of LT."
"Immunization with Tat and the two adjuvants induced in BALB/c but not in C57BL/6 mice high and persistent levels of serum IgG and secretory IgA in vaginal and intestinal fluids," reported Mariarosaria Marinaro and collaborators at the Istituto Superiore di Sanita and Chiron SpA. "Mice sera neutralized Tat and recognized two epitopes mapping in the regions 1-20 and 46-60. Furthermore, their splenocytes proliferated and secreted IFN-gamma and ...
- Mucosal delivery of HIV-1 Tat protein elicits strong immune response.
- Newspaper article from: AIDS Weekly November 10, 2003 700+ words
...NewsRx.net) -- Mucosal delivery of the human...immunodeficiency virus-1 Tat protein in mice elicits...virus (HIV)-1 Tat protein induces protection...in Vaccine (Mucosal delivery of the human...immunodeficiency virus-1 Tat protein in mice elicits...
- Lipopeptide MALP-2 effective adjuvant for mucosal delivery of HIV-1 protein.
- Newspaper article from: AIDS Weekly August 25, 2003 700+ words
...effective adjuvant for mucosal delivery of the HIV-1 Tat protein. "A major requirement...biologically active HIV-1 Tat protein as antigen and the...Immunology (Efficient mucosal delivery of the HIV-1 Tat protein using the synthetic...
- Targeted Polymerized Liposomes Evaluated For Mucosal Delivery.
- Newspaper article from: Immunotherapy Weekly April 23, 2000 700+ words
...proposed as carriers for vaccines for mucosal delivery," according to Robert N. Brey...could be used as a carrier vehicle for mucosal delivery of vaccines. However, they have...liposomes. "To provide for potential mucosal delivery enhancements, such liposomes have...
- Targeted Polymerized Liposomes Evaluated For Mucosal Delivery.(Brief...
- Newspaper article from: Vaccine Weekly April 19, 2000 700+ words
...proposed as carriers for vaccines for mucosal delivery," according to Robert N. Brey...could be used as a carrier vehicle for mucosal delivery of vaccines. However, they have...liposomes. "To provide for potential mucosal delivery enhancements, such liposomes have...
- Mutants of lactic acid bacteria enhance mucosal delivery of antigen.
- Newspaper article from: Health & Medicine Week July 5, 2004 700+ words
...of lactic acid bacteria enhance the mucosal delivery of antigen. According to recent research...resulted in a major improvement in the mucosal delivery of antigens exhibiting vaccine properties...Infection and Immunity (Enhanced mucosal delivery of antigen with cell wall mutants...
- Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by Recombinant Strains...
- Newspaper article from: Vaccine Weekly September 7, 1998 700+ words
...Robinson, K.; Chamberlain, L.; Schofield, K.M.; Remaut, E.; Lepage, R.W.F.; Wells, J.M. "Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by Recombinant Strains of Lactococcus lactis Coexpressing Antigen and Cytokine...
- Distribution Fate and Mechanism of Immune Modulation Following Mucosal Delivery...
- Newspaper article from: Vaccine Weekly September 27, 1999 700+ words
...Daheshia, M.; Lee, S.; Eo, S.K.; Rouse, B.T. "Distribution Fate and Mechanism of Immune Modulation Following Mucosal Delivery of Plasmid DNA Encoding IL-10." Journal of Immunology, September 1, 1999;163(5):2393-2402. (CW HENDERSON...
- Vaccine Delivery "Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by...
- Newspaper article from: Vaccine Weekly September 7, 1998 700+ words
Infection and Immunity, July 1998;66(7):3183-3189. Steidler, L.; Robinson, K.; Chamberlain, L.; Schofield, K.M.; Remaut, E.; Lepage, R.W.F.; Wells, J.M. According to the authors' abstract of an article published in Infection and Immunity, "Lactococcus lactis is a nonpathogenic and noncolonizing