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Delivery of antigens onto bare skin may provide painless vaccination.
2003 NOV 12 - (NewsRx.com & NewsRx.net) -- Delivery of antigens onto bare skin may provide painless vaccination.
"The skin is an attractive route for delivery of vaccines because it is accessible and contains immunocompetent cells. This opens up the possibility that, in the future, vaccines could be administered in a simple, safe, and practical way without requiring the use of needles and syringes. This review focuses on the methods developed to deliver vaccines via the intact skin," a scientist in France reports.
"Candidate vaccine antigens can be delivered topically using particulate delivery systems and patch formulations containing the antigen with an ADP-ribosylating exotoxin as an adjuvant," reported Charalambos D. Partidos at the Centre National de la Recherche Scientifique.
"The duration and type of elicited immune responses depend on the antigen, the adjuvant and the method of delivery. Already, the first clinical trial of transcutaneous delivery of vaccines has demonstrated the proof of the principle. However, despite these successes, ...
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Source: HighBeam Research, Delivery of antigens onto bare skin may provide painless vaccination.