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Fetal thrombophilic mutations are linked to intrauterine growth retardation.

Women's Health Weekly

| November 06, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Fetal thrombophilic mutations are linked to intrauterine growth retardation.

"This study was conducted to investigate the association of maternal and/or fetal factor V Leiden (FVL) and G20210A prothrombin mutation with HELLP syndrome. FVL and G20210A prothrombin mutation were determined using PCR. Sixty-three pregnant women, 36 of them diagnosed with HELLP syndrome, were included in the study," scientists in the United States report.

"Overall, 68 children were born as a result of these pregnancies and blood sampling was possible in 28 out of 39 children from HELLP patients and 25 out of 29 children from the control women."

"The prevalence of a maternal FVL was elevated 2-fold in HELLP patients compared with the control women [6 out of 36 (16.7%) compared with 2 out of 27 (7.4%); p=0.282]. None of the HELLP patients and only one woman in the control group was found to be positive for the G20210A prothrombin mutation (p=0.251)," reported D. Schlembach and colleagues, University of Texas, Medical Branch.

"The fetal carrier frequency was 4 out of 28 compared with 3 out of 25 for FVL (p=0.811), and 2 out of 28 compared with 1 out of 25 for G20210A prothrombin mutation (p=0.629). Intrauterine growth restriction (IUGR) was significantly higher in fetuses found to be positive for a thrombophilic mutation (p=0.022). IUGR occurred in ...

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