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BKCa channel activation explains how human chorionic gonadotropin relaxes uteri.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- BKCa channel activation explains how human chorionic gonadotropin relaxes uteri.
According to recent research from Ireland, "the uterorelaxant effect of human chorionic gonadotropin (hCG) is regarded as an important mediator in maintenance of uterine quiescence during pregnancy with clinical potential for tocolysis, the mechanisms of which are unknown. The large conductance calcium-activated K+ channel (BKCa) is ubiquitously encountered in human uterine tissue and plays a significant role in modulating myometrial cell membrane potential and excitability. The objective of this study was to investigate the involvement of BKCa channel function in the response of human myometrial cells to hCG."
"Single electrophysiological BKCa channel recordings from freshly dispersed myocytes were obtained in the presence and absence of increasing hCG concentrations. Isometric tension studies, investigating the effects of hCG on isolated myometrial contractions, in the presence and absence of the BKCa channel blocker, iberiotoxin, were performed," wrote wrote H.C. Doheny and colleagues, National University of Ireland, Galway, University College Hospital.
"The hCG significantly increased the open-state probability of these channels in a concentration-dependent manner [control 0.036[+ or -]0.01; 1 IU/ml hCG ...
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SOURCE: FEMS Microbiology Letters, September 1, 1992;96(1):27-30. Human chorionic gonadotropin (hCG) may protect unborn children against HIV-1 infection, an in vitro study suggests. New York researchers...
Source: HighBeam Research, BKCa channel activation explains how human chorionic gonadotropin...