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Raloxifene stimulates osteoprotegerin and blocks interleukin-6 production.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Raloxifene stimulates osteoprotegerin and blocks interleukin-6 production.
"Raloxifene reduces bone loss and prevents vertebral fractures in postmenopausal women. Its skeletal effects are mediated by estrogen receptors (ER) and their modulation of paracrine osteoblastic factors. Receptor activator of nuclear factor-kappaB ligand is essential for osteoclasts and enhances bone resorption, whereas osteoprotegerin (OPG) neutralizes receptor activator of nuclear factor-kappaB ligand," researchers in Germany report.
"Here, we assessed the effects of raloxifene on OPG production in human osteoblasts (hOB). Raloxifene enhanced gene expression of ER-alpha and progesterone receptor. Moreover, raloxifene increased OPG mRNA levels and protein secretion by hOB in a dose- and time-dependent fashion by 2- to 4-fold with a maximum effect at 10[superscript]-7 M and after 72 h (p
"Treatment with the ER antagonist ICI 182,780 abrogated the effects of raloxifene on OPG production. Moreover, raloxifene enhanced osteoblastic differentiation markers, type 1 collagen secretion, and alkaline phosphatase activity by 3- and 2-fold, respectively (p
Viereck and colleagues published their study in Journal of Clinical Endocrinology and Metabolism (Raloxifene ...
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Source: HighBeam Research, Raloxifene stimulates osteoprotegerin and blocks interleukin-6...