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Hyper-responsive genes in reproductive tissues could be a source for fetal harm.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Hyper-responsive genes in reproductive tissues could be a source for fetal harm.
According to a study from Mexico, "the identification of polymorphisms in genes encoding proinflammatory cytokines that affect transcription or the secretion rate has opened new ways to understand the variation in responses to infection during pregnancy. In this study, human amniochorion carrying hyper-responsive alleles of tumor necrosis factor-alpha (TNF-alpha: TNF*2 at -308) and interleukin-1beta (IL-1beta: IL-1*2 at +3953) were stimulated in vitro with bacterial lipopolysaccharide (LPS) and compared with tissues carrying the common alleles (TNF*1 and IL-1*1)."
"Fetal membranes carrying the TNF*1 allele displayed an identical dose-response pattern to tissues carrying a TNF*2 allele, except at the highest dose of LPS tested (50 ng/ml) there was a significantly greater production of TNF-alpha in the presence of a TNF*2 allele," reported C. Hernandez-Guerrero and colleagues, National Perinatology Institute.
"Membranes carrying the IL-1*2 polymorphism secreted IL-1beta in a dose-response curve that was different ...
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Source: HighBeam Research, Hyper-responsive genes in reproductive tissues could be a source for...