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HVJ envelope vector offers efficient gene transfer to the uterus.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- HVJ envelope vector offers efficient gene transfer to the uterus.
"The uterus is obviously critical in implantation, development of the fetus, and parturition. Endometrial cancer derived from endometrial epithelium is one of the common malignancies in the female reproductive tract. In order to clarify the local mechanisms of reproductive physiology and establish a non-systemic therapeutic strategy for reproductive failure as well as for endometrial cancer, we applied hemaggulutinating virus of Japan envelope (HVJ-E) vector to in-vivo gene transfer into the uterine cavity of IVCS mice," wrote researchers in Japan.
"Injection of HVJ-E vector into mouse uterine cavity on day 1.5 post coitum (p.c.) introduced a reporter gene approximately 120-fold more efficiently than introduction using the cationic liposome method. The expression of the introduced gene continued for at least 3 days," reported H. Nakamura and colleagues, Osaka University, Graduate School of Medicine.
"The plasmid vector was localized in the endometrial epithelium, whereas oligo deoxynucleotides were distributed throughout the epithelium, stromal cells and myometrium. HVJ-E vector did not affect the pregnancy rate, course of pregnancy, litter size, fetal growth in utero or ...
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- Magazine article from: BIOWORLD Today Leff, David N. March 5, 2003 700+ words
...limited largely by the low efficiency of gene transfer delivered by traditional viral vectors...efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes." "Our just...10-fold decrease in efficiency of gene transfer. Now, if gene transfer as a ...
Source: HighBeam Research, HVJ envelope vector offers efficient gene transfer to the uterus.