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New insights into how estrogen works may lead to improved stroke treatments.

Women's Health Weekly

| November 06, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 NOV 6 - (NewsRx.com & NewsRx.net) -- A team of researchers working in Texas and Florida have discovered new insights into how estrogen works, a finding that may lead to better treatments for stroke patients.

The researchers are from the University of North Texas Health Science Center at Fort Worth, Texas (UNTHSC) and the University of Florida's (UF) McKnight Brain Institute.

"We discovered a major mechanism by which estrogen protects nerve cells," said James Simpkins, PhD, director of UNTHSC's Institute for Aging and Alzheimer's Disease Research. "We now know how estrogen keeps brain cells alive even when exposed to an insult like stroke, Alzheimer's disease, or Parkinson's disease."

If a compound can retain estrogen's protective benefits and reduce the side effects because the estrogen is produced in a controlled fashion in the body, it could change the way strokes, heart attacks, and chronic conditions such as Alzheimer disease are treated, he said. "Essentially, patients will be able take advantage of the good effects of estrogen while minimizing the bad effects."

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