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Estrogen receptor alpha mediates the dynamics of orphan nuclear receptors.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Estrogen receptor alpha mediates the dynamics of orphan nuclear receptors.
"Hormonal status can influence diverse metabolic pathways. Small heterodimer partner (SHP) is an orphan nuclear receptor that can modulate the activity of several transcription factors. Estrogens are here shown to directly induce expression of the SHP in the mouse and rat liver and in human HepG2 cells," investigators in the United States report.
"SHP is rapidly induced within 2 hours following treatment of mice with ethynylestradiol (EE) or the estrogen receptor alpha (ERalpha)-selective compound propyl pyrazole triol (PPT). SHP induction by these estrogens is completely absent in ERalphaKO mice," explained K.D. Lai and colleagues, Wyeth Research.
"Mutation of the human SHP promoter defined HNF-3, HNF-4, GATA, and AP-1 sites as important for basal activity, whereas EE induction required two distinct elements located between - 309 and - 267. One of these elements contains an estrogen response element half-site that bound purified ERalpha, and ERalpha with a mutated DNA binding domain was unable to ...
- The p53 gene regulates estrogen receptor-alpha in breast cancer cells.
- Newspaper article from: Cancer Gene Therapy Week June 7, 2004 700+ words
...The p53 gene regulates estrogen receptor-alpha in breast cancer cells...demonstrate that p53 upregulates estrogen receptor-alpha (ERalpha) expression...Endocrinology (Regulation of estrogen receptor-alpha expression by the tumor...
- DNA shuffling helps generate estrogen receptor alpha and beta chimeras in yeast.
- Newspaper article from: Genomics & Genetics Weekly April 11, 2003 700+ words
...DNA shuffling to generate estrogen receptor alpha and beta chimeras in yeast...the molecular basis for the estrogen receptor (ER) subtype selectivity...shuffling method for generating estrogen receptor alpha and beta chimeras in yeast...
- Estrogen receptor-alpha mutation K303R not found in Japanese breast carcinomas.
- Newspaper article from: Biotech Week May 12, 2004 700+ words
...amp; NewsRx.net) -- Estrogen receptor-alpha mutation K303R was not...nucleotide 908, in the estrogen receptor-alpha (ERalpha) gene has...Treatment (No hypersensitive estrogen receptor-alpha mutation (K303R) in Japanese...
- Leptin activates estrogen receptor alpha in MCF-7 cells.
- Newspaper article from: Biotech Week July 14, 2004 700+ words
...functional activation of estrogen receptor alpha in MCF-7 cells. According...cancer progression." "Estrogen receptor alpha (ERalpha), which plays...functional activation of estrogen receptor alpha in MCF-7 cells. J Biol...
- S-palmitoylation modulates human estrogen receptor-alpha functions.
- Newspaper article from: Biotech Week June 16, 2004 700+ words
...palmitoylation modulates human estrogen receptor-alpha functions. According to...to a fraction of nuclear estrogen receptor-alpha (ER-alpha) localized...palmitoylation modulates human estrogen receptor-alpha functions. Biochem Biophys...
- Certain Styrene Oligomers Have Proliferative Activity on MCF-7 Human Breast...
- Magazine article from: Environmental Health Perspectives Ohyama, Ken-ichi Nagai, Fumiko Tsuchiya, Yoshiteru July 1, 2001 700+ words
...binding assays to human estrogen receptor [Alpha] (hER[Alpha]) he...estrogenic activities, human estrogen receptor [Alpha], MCF-7 cells, styrene...styrene oligomers to human estrogen receptor [Alpha] (hER[Alpha]) in...
- Spinal cord's neurons with estrogen receptor-alpha upregulated during pregnancy.
- Newspaper article from: OBGYN & Reproduction Week February 10, 2003 700+ words
...amp; NewsRx.net) -- "Estrogen receptor (ER) immunoreactivity...examine the expression of estrogen receptor alpha-in the spinal cord during...Neuroscience Research (Estrogen receptor-alpha and neural circuits to the...
- Estrogen receptor-alpha and beta are differentially expressed in the uterus.
- Newspaper article from: OBGYN & Reproduction Week January 5, 2004 700+ words
...5 - (NewsRx.com & NewsRx.net) -- Estrogen receptor-alpha and beta are differentially expressed in the...Endocrine Journal (Differential regulation of estrogen receptor alpha and beta mRNAs in the rat uterus during pregnancy...
- Bisphenol A at low nanomolar doses confers chemoresistance in estrogen...
- Magazine article from: Environmental Health Perspectives LaPensee, Elizabeth W. Tuttle, Traci R. Fox, Sejal R. Ben-Jonathan, Nira February 1, 2009 700+ words
...doxorubicin, cisplatin, and vinblastine in the estrogen receptor-[alpha] (ER[alpha])-positive T47D and the ER...is enigmatic. The binding affinity of BPA to estrogen receptor-[alpha] (ER[beta]) or ER[beta] is 10,000...
- Xenoestrogens at picomolar to nanomolar concentrations trigger membrane...
- Magazine article from: Environmental Health Perspectives Wozniak, Ann L. Bulayeva, Nataliya N. Watson, Cheryl S. April 1, 2005 700+ words
...selected for expression of high levels of membrane estrogen receptor-[alpha]. Picomolar to nanomolar concentrations of both...diethylstilbestrol, dieldrin, endosulfan, estrogen receptor-s, exocytosis, L-type channels, membrane...
Source: HighBeam Research, Estrogen receptor alpha mediates the dynamics of orphan nuclear...