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HPV DNA testing has a role in predicting cervical intraepithelial lesions.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- HPV DNA testing has a role in predicting cervical intraepithelial lesions.
According to recent research from the United States, "Human papillomavirus (HPV) is widely accepted as the primary agent involved in the development of squamous intraepithelial neoplasia and cervical carcinoma. Several commercial tests a re available for detecting HPV DNA.
"This study compares the efficacy of INFORMHPV (in situ hybridization [ISH] HPV) and HCII (HC HPV) in predicting cervical lesions. A total of 762 sequential Papanicolaou (Pap) smears determined by cytologic examination to be either atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL) were tested by both Hybrid Capture (HC) HPV and ISH HPV; 250 follow-up biopsies were reviewed as the reference standard for presence or absence of a lesion," wrote M.N. Qureshi and colleagues, Bayonne Medical Center.
"ISH HPV and HC HPV differed significantly in accurately predicting biopsy findings from ASC-US and LSIL cases. The overall sensitivity and specificity of ISH HPV were 97% (28129) and 86% (191/221); and HC HPV was 79% (23/29) and 56% (123/221)," the researchers wrote.
"The positive predictive value (PPV) of ISH HPV was 48% (28/158) vs. HC HPV value of 19% (23/121). Negative predictive value (NPV) was ...
- Product Briefs.
- Newspaper article from: Diagnostics & Imaging Week September 4, 2003 700+ words
...report, the authors describe the sensitivity, specificity, positive and negative predictive values of the Ventana Inform ISH HPV DNA assay and the Digene (Gaithersburg, Maryland) HC2 assay. The data presented in the study were generated, in part...
- Ventana's INFORM HPV Assay and Benchmark System Used in Study of Cervical...
- Press release article from: Business Wire August 28, 2003 700+ words
...the authors describe the sensitivity, specificity, positive, and negative predictive values of the Ventana INFORM(R) ISH HPV DNA assay and the Digene Corp. HC2 assay. The report can be accessed electronically at www.interscience.wiley.com...
Source: HighBeam Research, HPV DNA testing has a role in predicting cervical intraepithelial...