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Skin, normally below physiologic temperature, enables C. albicans mating.

Women's Health Weekly

| November 06, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Skin that is normally below physiologic temperature is at conditions favorable for Candida albicans to mate.

"Mating between natural a/a and alpha/alpha strains of Candida albicans requires that cells first switch from the white to opaque phase phenotype. However, because cells expressing the opaque phase phenotype are induced to switch back to the white phase phenotype at physiological temperature (37 degrees C) and because opaque phase cells are highly efficient at colonizing skin, we tested whether skin, which is several degrees lower than physiological temperature, is conducive to mating," scientists writing in the journal Infection and Immunity report.

"Using a model in which a mixture of a/a and alpha/alpha cells are incubated for 24 h under a cotton patch on the hairless skin of newborn mice and using scanning electron microscopy to visualize cells on skin, it was demonstrated that skin facilitates mating. In some regions of the skin, 40% of all cells had fused. All of the stages of mating observed in vitro were observed in vivo. However, some unique morphological characteristics ...

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