Hormonal factors associate with the risk for Hodgkin disease in women.

2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Hormonal factors associate with the risk for Hodgkin disease in women.

"Reproductive factors have been suggested to have an impact on the development of Hodgkin disease (HD) in women. In the San Francisco Bay Area, the authors conducted a population-based case-control study addressing the effects of reproductive experience and hormone use on HD risk. Cases were 370 women with HD diagnosed at ages 19-79 years between July 1988 and December 1994," scientists in the United States report.

"Controls were 450 community women found through random digit dialing. Among the 312 cases and 325 controls interviewed, HD risk was related to parity versus nulliparity but only among never nursers (odds ratio (OR)=2.2, 95% confidence interval (CI): 1.0, 5.0)," wrote S.L. Glaser and colleagues, Northern California Cancer Center.

"Risk was marginally related to having uterine fibroids (OR=0.6, 95% CI: 0.5, 1.0) and long-term versus short-term hormone use (OR=0.7, 95% CI: 0.4, 1.0) and was significantly related to recurrent miscarriage (OR=2.8, 95% CI: 1.1, 7.4)."

"Among women aged 35-54 years, for whom the sex difference in incidence is largest, nursing decreased risk; among never nursers, a ...