AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Interactions between breast cancer, osteoblastic cells induce osteoclastogenesis.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Direct interactions between breast cancer and stromal or osteoblastic cells induce osteoclastogenesis through modulating RANKL expression.
"Bone destruction is primarily mediated by osteoclastic bone resorption, and cancer cells stimulate the formation and activation of osteoclasts next to metastatic foci," scientists in South Korea report.
"Accumulating evidences indicate that receptor activator of NFkappaB ligand (RANKL) is the ultimate extracellular mediator that stimulates osteoclast differentiation into mature osteoclasts. In contrast, osteoprotegerin (OPG) inhibits osteoclast development," wrote H.R. Park and colleagues, Hallym University, Sacred Heart Hospital.
"In order to elucidate a mechanism for cancer-induced osteoclastogenesis, cells from a human breast cancer line, MDA-MB-231, were directly co-cultured with ST2, MC3T3-E1, or with primary mouse calvarial cells. Osteoclast-like cells and tartarate resistant acid phosphatase (TRAP) activities were then quantitated," the researchers wrote.
"We examined these cell lines and samples from breast cancer by RT-PCR for the expressions of OPG and RANKL mRNA. Compared to controls, co-culture of MDA-MB-231 cells with stromal or osteoblastic cells induced an ...
- South Korea Breast Cancer Awareness Campaign
- Picture from: AP Images Ahn Young-joon October 7, 2009 700+ words
Pink umbrellas and balloons are displayed over a stream to promote the Breast Cancer Awareness Campaign in Seoul, South Korea, Wednesday, Oct. 7, 2009.(AP Photo/Ahn Young-joon)
- APTOPIX South Korea Breast Cancer Awareness Campaign
- Picture from: AP Images Ahn Young-joon October 7, 2009 700+ words
Pink umbrellas and balloons are displayed over a stream to promote the Breast Cancer Awareness Campaign in Seoul, South Korea, Wednesday, Oct. 7, 2009.(AP Photo/Ahn Young-joon)
- South Korea FDA approves Abraxane for metastatic breast cancer.
- Newspaper article from: Pharma Marketletter April 14, 2008 700+ words
...granted marketing approval for Abraxane (paclitaxel albumin-bound particles for injectable suspension) for the treatment of metastatic breast cancer after failure of standard chemotherapy. The agent is also currently approved in the USA.
- Studies conducted at I.H. Park et al on breast cancer recently published.
- Newspaper article from: Cancer Weekly August 18, 2009 700+ words
...scientists in South Korea report (see also Breast Cancer). "We assessed...Center, Center Breast Cancer, Goyang Si, South Korea. Publisher contact...England. Keywords: South Korea, Bone Disease, Breast Cancer, Breast Carcinoma...
- Plasma D-dimer identifies lymph node metastasis in breast cancer patients.
- Newspaper article from: Biotech Week June 30, 2004 700+ words
...node metastasis in breast cancer," researchers in South Korea report. "Preoperative...120 patients (93 breast cancer, 27 benign breast...patients with operable breast cancer as a potential...Geonggi Do, South Korea. Publisher contact...
- S. Korea's breast cancer deaths up sharply in last 10 years.
- News wire article from: YON - Yonhap News Agency of Korea October 11, 2007 700+ words
...Oct. 10 (Yonhap) -- Breast cancer deaths in South Korea have risen 53.5 percent...every 100,000 died from breast cancer last year. This is a sharp...attending the three-day Global Breast Cancer Conference 2007, said the...
- Research from Ajou University reveals new findings on breast cancer.(Report)
- Newspaper article from: Cancer Weekly July 28, 2009 700+ words
...Kim, Ajou University, School Medical, Breast Cancer Center, Suwon 441749, South Korea. The publisher of the journal Biological Trace...NJ 07512, USA. Keywords: South Korea, Breast Cancer, Breast Carcinoma, Chemotherapy, Community...
- Researchers from Seoul National University, Medical Department detail findings...
- Newspaper article from: Cancer Weekly June 30, 2009 700+ words
...in the urine of breast cancer patients," scientists in Seoul, South Korea report (see also Breast Cancer). "Reactive spots...USA. Keywords: South Korea, Seoul, Autoimmune...Biotechnology, Breast Cancer, Breast Carcinoma...