AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Circulating tumor DNA may not be accurate reflection of breast cancer status.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Circulating tumor DNA may not be a sufficiently accurate reflection of breast cancer clinical status or tumor activity.
"We evaluated the potential utility of occult circulating tumor DNA as a molecular marker of disease in subjects previously diagnosed with breast cancer. Using 24 microsatellite markers located at sites of frequent loss of heterozygosity (LOH) or allele imbalance in breast cancer, we analyzed DNA from 16 primary tumors (Stage IIA or more advanced) and 30 longitudinally collected plasma specimens," researchers in the United States report.
"Clinical data at the time of plasma collection were obtained. All 16 tumors were characterized by an individual pattern of LOH. LOH was detected in 12 of 30 (40%) plasma samples, taken from eight of 14 (57%) subjects. However, the number of LOH in plasma was small (n=15), and the mean proportion of LOH was much lower than in the tumors (.05 vs. 0.52)," wrote Q. Wang and colleagues, Boston University Medical Center.
"Although infrequent, 12 of 15 (80%) plasma LOH were concordant with abnormalities in the paired tumors, and the mean percent LOH was higher than in normal plasmas, suggesting that they were authentic tumor-derived abnormalities. We found, despite this, no association, between plasma LOH and tumor stage or clinical status at time of blood collection (i.e., LOH was as common in subjects with no evident disease as in those with evident disease)," the researchers wrote.
"In ...
- Pooled analysis of LOH in breast cancer finds many nonreproducible results.
- Newspaper article from: Health & Medicine Week February 2, 2004 700+ words
...of heterozygosity (LOH) studies of breast cancer that lays a framework...of heterozygosity (LOH) has been widely reported in breast cancer as a means of identifying...from 151 published LOH studies of breast cancer, with summary data...
- Microsatellite instability and LOH was found at specific growth and death...
- Newspaper article from: Cancer Weekly February 25, 2003 700+ words
...loss of heterozygosity (LOH) was investigated in...predominantly premenopausal breast cancer patients (under age...D13S796 (20%). "LOH was seen at a single...Occurrence of MSI or LOH was unrelated to clinical...younger age of onset breast cancer population. Int J Mol...
- Molecular analysis of ductal fluid provides data about breast cancer markers.
- Newspaper article from: Health & Medicine Week April 19, 2004 700+ words
...mutation carriers with BRCA1 LOH, invasive breast cancer was subsequently detected...tumor showed the same LOH as the DL. In one of...published their study in Breast Cancer Research and Treatment (Detection of LOH and mitochondrial DNA...
- Microsatellite instability and LOH was found at specific growth and death loci.
- Newspaper article from: Cancer Gene Therapy Week February 24, 2003 700+ words
...loss of heterozygosity (LOH) was investigated in...predominantly premenopausal breast cancer patients (under age...D13S796 (20%). "LOH was seen at a single...Occurrence of MSI or LOH was unrelated to clinical...younger age of onset breast cancer population. Int J Mol...
- New breast cancer study findings have been reported by researchers at Kumamoto...
- Newspaper article from: Blood Weekly December 11, 2008 700+ words
...In this study, breast cancer specimens as well...were screened for LOH using 6 polymorphic...University (see also Breast Cancer). The researchers...mechanisms, deletions ( LOH), or mutations...minimal region in breast cancer. BMC Cancer...
- Study data from University of Texas provide new insights into breast cancer.
- Newspaper article from: Cancer Weekly August 4, 2009 700+ words
...underlie early-onset breast cancer." "Here we report...survival in early-onset breast cancer. and Findings: Suppression...loss of heterozygosity (LOH) in a number of histologically...were discovered in breast cancer cell lines and tumor...
- Unique loss of heterozygosity patterns exist in different breast cancer groups.
- Newspaper article from: Biotech Week March 24, 2004 700+ words
...Researchers find unique LOH patterns in different groups of breast cancer, in part defined by expression...alterations (loss of heterozygosity; LOH) with subclasses of breast...arrays (Affymetrix, Inc.). LOH was determined by comparing...
- New breast cancer data have been reported by D.M. Jukic and co-authors.
- Magazine article from: Women's Health Weekly November 19, 2009 700+ words
...unequivocally; therefore, LOH profiles were performed on archival...carcinomas showed disparate LOH at 5 of 7 (right breast) and...eccrine carcinoma revealed no LOH at the tested loci, establishing...Jukic and colleagues (see also Breast Cancer). The researchers concluded...