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Breast cancer classification, prognosis can be based on gene expression profiles.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Breast cancer classification, prognosis can be based on gene expression profiles.
"Comprehensive gene expression patterns generated from cDNA microarrays were correlated with detailed clinicopathological characteristics and clinical outcome in an unselected group of 99 node-negative and node-positive breast cancer patients," researchers in the United States report.
"Gene expression patterns were found to be strongly associated with estrogen receptor (ER) status and moderately associated with grade, but not associated with menopausal status, nodal status, or tumor size," wrote C. Sotiriou and colleagues, National Cancer Institute, Division of Clinical Science.
"Hierarchical cluster analysis segregated the tumors into two main groups based on their ER status, which correlated well with basal and luminal characteristics. Cox proportional hazards regression analysis identified 16 genes that were significantly associated with relapse-free survival at a stringent significance level of .001 to account for multiple comparisons," the researchers wrote.
"Of 231 genes previously reported by others [van't Veer, L. J., et al Nature, 2002;415, 530-536] as being associated with survival, 93 probe elements overlapped with the set of 7,650 probe elements represented on the arrays used in this study. Hierarchical cluster analysis based on the set of 93 probe elements segregated our population into two distinct subgroups with different ...
- Towards a holistic, yet gene-centered analysis of gene expression profiles: a...
- Magazine article from: Journal of Biomedicine and Biotechnology Guo, Yuchun Eichler, Gabriel S. Feng, Ying Ingber, Donald E. Huang, Sui January 1, 2006 700+ words
...inspector (GEDI) to analyze gene expression profiles of various lung tumors...8]. For example, gene expression profiles have been used to classify...has gained importance as gene expression profiles for increasingly large...
- Gene expression profiles associated with inflammation, fibrosis, and...
- Magazine article from: Environmental Health Perspectives Gant, Timothy W. Baus, Petra R. Clothier, Bruce Riley, Joan Davies, Reginald Judah, David J. Edwards, Richard E. George, Elisabeth Greaves, Peter Smith, Andrew G. May 15, 2003 700+ words
...griseofulvin. Characteristic gene expression profiles could be associated with griseofulvin-induced gene expression, disruption of lipid metabolism...injury is through the use of gene expression profiles. Griseofulvin is an antifungal...
- Alcoholic liver disease patients have distinctive gene expression profiles.
- Newspaper article from: Biotech Business Week January 26, 2004 700+ words
...patients have distinctive gene expression profiles. According to a study...altered molecules in ALD. Gene expression profiles of ALD in a baboon model...pathogenesis. Overall gene expression profiles were similar in both species...
- Muscle gene expression profiles change as women age.
- Newspaper article from: Biotech Week May 19, 2004 700+ words
...NewsRx.net) -- Muscle gene expression profiles change as women age...on the differences in gene expression profiles between younger and older...Gerontology (Skeletal muscle gene expression profiles in 20-29 year old and...
- Curidium Discovers Significant Diagnostic Gene Expression Profiles in Blood of...
- Press release article from: PR Newswire March 21, 2007 700+ words
...significantly different (p<0.001) diagnostic gene expression profiles in blood samples from schizophrenia/bipolar...Homomatrix, Curidium's proprietary tool, the gene expression profiles of 115 schizophrenia/bipolar disorder patients...
- Gene expression profiles define key checkpoint for type 1 diabetes.
- Newspaper article from: Biotech Week April 7, 2004 700+ words
...NewsRx.net) -- Gene expression profiles define a key checkpoint...rapid switch of gene expression occurring around...the NOD. The expression profiles are consistent...in Diabetes (Gene expression profiles define a key checkpoint...
- Gene expression profiles reveal the toxicity endpoints of hepatotoxicants.
- Newspaper article from: Health & Medicine Week July 26, 2004 700+ words
...amp; NewsRx.net) -- Gene expression profiles reveal the toxicity endpoints...were used to investigate gene expression changes associated with hepatotoxicity...of the work was to define gene expression profiles capable of distinguishing...
- Gene Logic and Fujisawa Pharmaceutical Sign Collaborative Discovery Research...
- Press release article from: PR Newswire December 2, 1999 700+ words
...examples of the potential uses of gene expression information by a pharmaceutical...Logic will use its proprietary gene expression analysis tools and Affymetrix...these technologies to study gene expression profiles in tissues involved in diabetes...
Source: HighBeam Research, Breast cancer classification, prognosis can be based on gene...