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Apoptosis assays could be used to detect selective toxicity of anticancer drugs.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Apoptosis assays could be used to detect selective toxicity of anticancer drugs.
"The goal of our study was to determine whether an apoptosis assay used after short-term drug exposure could predict selective toxicity to cancer cells. To this end we compared the effect of 8 anticancer drugs and 10 toxic compounds without known antitumor activity in cultures of human breast cancer cells and normal diploid fibroblasts by Apoptosis ELISA and growth inhibition assays," investigators in the United States report.
"There was an overlap in concentration values of drugs and toxins inhibiting proliferation in cancer cells. In contrast, Apoptosis ELISA clearly distinguished between the two groups of compounds," wrote O.S. Frankfurt and colleagues, University of Miami School of Medicine.
"Anticancer drugs induced apoptosis in cancer cells at 0.0015-0.5 microM, while toxins were effective at much higher concentrations of 8.050 microM. Moreover, six out of the 10 toxins did not induce apoptosis in cancer cells," the researchers wrote.
"The normal:cancer cell (N:C) ratio for growth-inhibiting concentrations was in a similar range for anticancer drugs and ...
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- Apoptosis assays could be used to detect selective toxicity of anticancer drugs.
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