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Acetylated Sp3 is a transcriptional activator.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Acetylated Sp3 is a transcriptional activator.
According to a study from the United States, "Sp3 transcription factor can either activate or repress target gene expression.
"However, the molecular event that controls this dual function is unclear. We previously reported (Ammanamanchi S and Brattain MG, J Biol Chem, 2001;276, 3348-3352) that unmodified Sp3 acts as a transcriptional repressor of transforming growth factor-beta receptors in MCF-7L breast cancer cells," wrote S. Ammanamanchi and colleagues, Roswell Park Cancer Institute, Department of Pharmacology & Therapeutics.
"We now report that histone deacetylase inhibitor trichostatin A (TSA) induces acetylation of Sp3, which acts as a transcriptional activator of transforming growth factor-beta receptor type II (RII) in MCF-7L cells. Mutation analysis indicated the TSA response is mediated through a GC box located on the RII promoter, which was previously identified as an Sp1/Sp3-binding site that was critical for RII promoter activity," the researchers wrote.
"Ectopic Sp3 expression in Sp3-deficient MCF-7E breast cancer cells repressed RII promoter activity in the absence of TSA. However, in the TSA-treated MCF-7E cells ectopic Sp3 activated RII promoter," the researchers ...
- Acetylated Sp3 is a transcriptional activator.
- Newspaper article from: Cancer Vaccine Week November 3, 2003 700+ words
...acts as a transcriptional activator of transforming...located on the RII promoter, which was...activated RII promoter," the researchers...mediated RII promoter activity...Sp3 is a transcriptional activator. J Biol...
- Transcriptional activator promotes chromium stores in Saccharomyces.
- Newspaper article from: Biotech Week March 3, 2004 700+ words
...NewsRx.net) -- The putative transcriptional activator MSN1 promotes chromium accumulation...been inserted at nt 741 of the transcriptional activator, MSN1," stated K.S. Chang...cerevisiae is promoted by the transcriptional activator MSN1." Chang and associates...
- MafA is a glucose-regulated transcriptional activator for the insulin gene.
- Newspaper article from: Diabetes Week February 24, 2003 700+ words
...family, as the RIPE3b-binding transcriptional activator." "Reverse transcription...specific and glucose-regulated transcriptional activator for insulin gene expression and...pancreatic beta-cell-specific transcriptional activator for the insulin gene. J Biol...
- Rad9 acts as a transcriptional activator of gene expression.
- Newspaper article from: Biotech Week November 24, 2004 700+ words
...functions, the Rad9 protein can act as a transcriptional activator of gene expression. "The human Rad9 gene...novel function for human Rad9 protein as a transcriptional activator of gene expression. Cell Cycle, 2004...
- Upstream stimulatory factor is a transcriptional activator of CYP1A2.
- Newspaper article from: Proteomics Weekly June 30, 2003 700+ words
...Upstream stimulatory factor appears to be a transcriptional activator of CYP1A2, an abundant cytochrome in the...support the role of USF as a constitutive transcriptional activator of human CYP1A2." Pickwell and coauthors...
- Publication No. WO/2009/094527 Published on July 30, Assigned to Pioneer...
- News wire article from: US Fed News Service, Including US State News August 7, 2009 700+ words
GENEVA, Aug. 7 -- Shoba Sivasankar, David A. Selinger and Norbert Brugiere, all from the U.S., have developed a transcriptional activators involved in abiotic stress tolerance. The patent has been assigned to Pioneer Hi-Bred International Inc., Johnston, Iowa. According to an abstract posted by the
- Researchers at University of Caen have published new data on life sciences.
- Newspaper article from: Biotech Week December 24, 2008 700+ words
...through Sp1 site located at position -25 of human T beta RII promoter." "Inhibition of transcription factors binding (decoy...kappa B, which therefore may indirectly interact with T beta RII promoter. Altogether, these data suggest that IL-1 beta decreases...
- Transcriptional Repressor Of Transforming Growth Factor-B Identified.
- Newspaper article from: Gene Therapy Weekly April 5, 2001 700+ words
...to a luciferase reporter gene. In both MCF-7E and GEO cells, the cotransfection resulted in a 70% reduction in RI and RII promoter activity. Interestingly, RI and RII transcription was also repressed in MCF-7E cells when Sp3 was expressed ectopically...
