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Abnormal methylation of tumor suppressor genes occurs in sporadic breast cancer.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Abnormal methylation of several tumor suppressor genes occurs in sporadic breast cancer.
"Multiplex methylation-sensitive PCR was employed in studying the methylation of CpG islands in the RB1, p16/CDKN2A, p15/CDKN2B, p14/ARF, CDH1, MGMT, HIC1, and N33 promoter regions in breast cancer (105 tumors)," researchers in Russia report.
"Methylation was often observed for the two major suppressor genes involved in controlling the cell cycle through the Cdk-Rb-E2F signaling pathway, RB1 (18/105, 17%) and p16 (59/105, 56%); both genes were methylated in 13 tumors," wrote V.V. Zemlyakova and colleagues, Russian Academy of Medical Science, Medical Genetics Research Center.
The researchers concluded: "Methylation involved p15 in two (2%) tumors; CDH1, in 83 (79%) tumors; MGMT, in eight (8%) ...
- Tumor suppressor genes in breast cancer.(Brief article)(Book review)
- Magazine article from: SciTech Book News March 1, 2009 700+ words
9781604563269 Tumor suppressor genes in breast cancer. Lacroix, Marc Nova Biomedical Books 2008 114 pages...RC280 Among the genes that are altered in the onset of breast cancer are those that suppress tumors. Lacroix reviews the...
- Multiple suppressor genes may exist on the short arm of chromosome 8.
- Magazine article from: Women's Health Weekly August 7, 2003 700+ words
...multiple tumor suppressor genes may be located...8 into two breast cancer cell lines...multiple suppressor genes may exist on...8 into two breast cancer cell lines...vitro growth suppressor genes. Cancer Genet...
- Candidate tumor-suppressor genes identified on chromosome arm 8p.
- Newspaper article from: Cancer Weekly September 21, 2004 700+ words
...potential tumor-suppressor genes on chromosome...more tumor-suppressor genes (TSGs...dichotomy of breast cancer clinicopathologic...Candidate tumor-suppressor genes on chromosome...subject areas of Breast Cancer, Genomics...
- SAFB1 and SAFB2 may be novel breast tumor suppressor genes.
- Newspaper article from: Genomics & Genetics Weekly January 9, 2004 700+ words
...novel breast tumor suppressor genes, researchers say...Breast Center. "In breast cancer cells, SAFBs function...lost in clinical breast cancer specimens," the...novel breast tumor suppressor genes, and how they might...
- TSLC1 gene is one of the target tumor suppressor genes of nasopharyngeal cancer.
- Newspaper article from: Health & Medicine Week February 9, 2004 700+ words
...Multiple candidate tumor suppressor genes (TSG) were mapped to this...NSCLC), liver cancer, and breast cancer No somatic mutations of TSLC1...is one of the target tumor suppressor genes of this endemic cancer. Hui...
- Candidate tumor suppressor genes at FRA7G do not suppress malignancy.
- Newspaper article from: Cancer Gene Therapy Week May 12, 2003 700+ words
...NewsRx.net) -- Candidate tumor suppressor genes at FRA7G do not suppress malignancy...site containing the candidate tumor suppressor genes CAV1, CAV2, and TESTIN (TES...CAV2, and TESTIN are not tumor suppressor genes in this gastric cancer," the researchers...
- Tumor suppressor genes in hepatocellular carcinoma have aberrant profiles.
- Newspaper article from: Health & Medicine Week October 13, 2003 700+ words
...com & NewsRx.net) -- Tumor suppressor genes in hepatocellular carcinoma have aberrant...Recent studies suggest that tumor suppressor genes (TSGs) can also be silenced through...promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J...
- Arthritis suppressor genes TIA-1 and TTP vanquish arthritogenic cytokines.
- Newspaper article from: Biotech Week April 7, 2004 700+ words
...amp; NewsRx.net) -- Arthritis suppressor genes TIA-1 and TTP vanquish arthritogenic...1 and TTP function as arthritis suppressor genes: TIA-1(-/-) mice develop mild...Academy of Sciences USA (Arthritis suppressor genes TIA-1 and TTP dampen the expression...
