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Luminescent imaging is a useful tool for evaluating anticancer drugs in vivo.
2003 NOV 6 - (NewsRx.com & NewsRx.net) -- Luminescent imaging is a useful tool for evaluating anticancer drugs in vivo.
"Human DU-145 prostate and MCF-7 breast tumor cell lines were stably transfected with plasmid pcDNA3.1-Luc expressing firefly luciferase. Studies were performed with the transfected cell lines to evaluate luminescent imaging for measuring the efficacy of anticancer agents," scientists writing in the journal Anticancer Drugs report.
"In vitro experiments demonstrated a dose response of both cell lines to topotecan (Hycamtin) with an IC[subscript]50 of 0.013 microM for MCF-7 Luc cells and 0.002 microM for DU-145 Luc cells. In vivo imaging experiments were performed using athymic nude mice inoculated i.p. with 5 x 10[superscript]6 MCF-7 cells or s.c. with 5 x 10[superscript]6 DU-145 cells and then treated with topotecan at 2.5 mg/kg body weight," wrote G. Caceres and colleagues, Rumbaugh Goodwin Cancer Research Institute, Inc.
"Tumor progression and regression were monitored for 27 days. Animals inoculated s.c. with DU-145 Luc cells and then treated with topotecan demonstrated significant tumor growth and regression as measured with calipers and luminescent imaging," the researchers wrote.
"High correlation was observed between caliper and imaging results. The correlation coefficient was 0.75 for the control ...
- Luminescent imaging.(New Products)
- Magazine article from: Bioscience Technology November 1, 2003 700+ words
The LAS-3000 im-aging system utilizes a Super CCD Arca Type imaging chip that provides increased faint-light image capture while maintaining image clarity, resulting in high resolution image files It offers more than 4 orders of magnitude linearity. Features include a filter turret, additional
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- Magazine article from: Science News Decker, C. March 24, 1990 700+ words
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- Press release article from: Business Wire October 21, 2004 700+ words
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...which could speed development of new anticancer drugs by identifying specific cancer types...known clinical activity of existing anticancer drugs, correctly identifying cancers in...patterns of drug activity in established anticancer drugs, nor could these earlier systems...
- Lorus Therapeutics allowed Canadian patent to protect its novel anticancer...
- Press release article from: PR Newswire November 10, 2004 700+ words
...target R1 and R2, including its lead anticancer drugs in the clinic, GTI-2401 and GTI...Therapeutics is focused on developing anticancer drugs which complement the efficacy of more...building a portfolio of promising anticancer drugs. Late-stage clinical development...
- K-State Student Researches Chemical Compounds to Improve Performance of...
- Press release article from: M2 Presswire January 5, 2009 700+ words
...Compounds to Improve Performance of Anticancer Drugs(C)1994-2009 M2 COMMUNICATIONS...MANHATTAN -- Many potentially useful anticancer drugs never reach their full capability...Park, is researching how to improve anticancer drugs by altering the physical properties...
Source: HighBeam Research, Luminescent imaging is a useful tool for evaluating anticancer drugs...