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Tetanus toxoid and E. coli enterotoxin possess potent adjuvant activity.
2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Transcutaneous immunization with tetanus toxoid and mutants of Escherichia coli heat-labile enterotoxin as adjuvants elicit strong protective antibody responses.
According to a study from France, "In this study, the adjuvanticity of 2 nontoxic derivatives (LTK63 and LTR72) of heat-labile enterotoxin of Escherichia coli (LT) was evaluated and was compared with that of a cytosine phosphodiester-guanine (CpG) motif, after transcutaneous immunization with tetanus toxoid (TT)."
"TT plus LTR72 elicited the strongest antibody responses, compared with those elicited by the other vaccines (TT, TT plus LTK63, TT plus CpG, and TT plus LTK63 plus CpG); it neutralized the toxin and conferred full protection after passive transfer in mice," reported Rob Tierney and collaborators at the National Institute for Biological Standards and Control in the U.K., Centre National de la Recherche Scientifique in France, and Chiron SpA in Italy.
The authors continued, "Preexisting immunity to LT mutants did not adversely affect their adjuvant potency. Both LTK63 and LTR72 promoted the induction of IgG1 antibodies. In contrast, mice receiving either CpG motif alone or CpG ...
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- tetanus toxoid
- Reference information from: The Mosby Medical Encyclopedia October 1, 1996 700+ words
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- Safety and Immunogenicity Results Available for New Tetanus Toxoid, Reduced...
- Press release article from: PR Newswire November 1, 2004 700+ words
...GlaxoSmithKline today reported results from a pivotal clinical study of its booster vaccine candidate, Boostrix(TM) [Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed (Tdap)]. The Phase III clinical trial involved...
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Adacel (tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, adsorbed, Aventis Pasteur) The Food and Drug Administration approved...
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...Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices voted at its summer meeting. Two Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed (Tdap) products were licensed for single-dose...
