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2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Vaccination with nontoxic mutant toxic shock syndrome toxin 1 protects against Staphylococcus aureus infection.
"To investigate whether vaccination with nontoxic mutant toxic shock syndrome toxin 1 (mTSST-1) can protect against Staphylococcus aureus infection, mice were vaccinated with mTSST-1 and challenged with viable S. aureus. Survival in the mTSST-1-vaccinated group was higher, and bacterial counts in organs were significantly lower than those of control mice," scientists in Japan report.
"Passive transfer of mTSST-1-specific antibodies also provided protection against S. aureus-induced septic death," said Dong-Liang Hu and collaborators at Hirosaki University, Iwate University, and the National Institute of Animal Health of Japan. "Interferon (IFN)-gamma production in the serum samples and spleens from vaccinated mice was significantly decreased compared with that in controls, whereas interleukin-10 titers were significantly higher in vaccinated mice. IFN-gamma and tumor necrosis factor-alpha production in vitro were significantly inhibited by serum samples from mTSST-1-immunized mice but not from control ...
Source: HighBeam Research, Mutant toxic shock syndrome toxin 1 prevents Staphylococcus infection.