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Poliovirus type 2 vaccine elicits strongest immune response in children.
2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The poliovirus type 2 vaccine elicited a stronger immune response than did type 1 or 3 in Finnish children.
"A total of 32 unimmunized children (median age 5 months) living in an orphanage in Minsk, Belarus, were vaccinated with three doses of oral poliovirus vaccine (OPV) with a 60-day interval between the doses. Blood samples were drawn before the immunizations and 45-50 days after each vaccine dose. Excretion of the vaccine viruses was followed by examining fecal specimens collected weekly after each vaccine dose," scientists in Finland report.
"All children seroconverted by the second dose of OPV at the latest to all three serotypes of poliovirus but differences were seen regarding the intestinal responses," stated Elena Samoilovich and colleagues at the Ministry of Health and the National Public Health Institute. "The strongest responses in both neutralizing antibodies and virus-binding IgA in fecal suspensions were seen toward poliovirus type 2. Consistent with this, relatively little poliovirus type 2 excretion was seen after the second and third doses of OPV as compared to that of poliovirus type 1 or type 3. The delayed development of functional intestinal immunity against the latter serotypes was associated with relatively weaker intestinal antibody responses compared to poliovirus type 2."
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Source: HighBeam Research, Poliovirus type 2 vaccine elicits strongest immune response in...