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Her-2/neu is potential vaccine target for acute lymphoblastic leukemias.
2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The Her-2/neu antigen is a potential vaccine target for acute lymphoblastic leukemias.
"Her-2/neu is a tumor-associated antigen that is expressed on several adenocarcinomas and correlates with poor prognosis. In a previous study, it has been demonstrated that Her-2/neu expression can be detected on blast cells from patients with hematological malignancies including acute lymphoblastic leukemia (ALL)," scientists in Germany report.
"Here, we show that Her-2/neu-specific CTLs induced in vitro using peptide-pulsed dendritic cells efficiently lyse primary ALL blasts constitutively expressing both Her-2/neu and human leukocyte antigen A2 in an antigen-specific and MHC-restricted manner," said Martin R. Muller and colleagues at the University of Tubingen. "Furthermore, we analyzed the feasibility of this approach in an autologous setting and induced Her-2/neu-specific CTLs using dendritic cells generated from peripheral blood mononuclear cells from an ALL patient that were pulsed with peptides or transfected with in vitro-transcribed Her-2/neu mRNA."
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Source: HighBeam Research, Her-2/neu is potential vaccine target for acute lymphoblastic...