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Virus delivered nitroreductase/CB1954 acts synergistically with 5-FU on cancer.
2003 NOV 5 - (NewsRx.com & NewsRx.net) -- The enzyme-prodrug combination nitroreductase/CB1954 creates cancer cell apoptosis by the caspase pathway, and acts synergistically with 5-fluorouracil.
According to published research from England, "Virus-directed enzyme prodrug therapy (VDEPT) utilizing the bacterial enzyme nitroreductase delivered by a replication-defective adenovirus vector to activate the prodrug CB1954 is a promising strategy currently undergoing clinical trials in patients with a range of cancers.
"An understanding of the mechanism of tumor cell death induced by activated CB1954 will facilitate this clinical development. Here we report that activated CB1954 kills cells predominantly by caspase-dependent apoptosis. This may have important implications for the generation of immune-mediated bystander effects. Furthermore, the use of a replication-defective adenovirus vector to deliver nitroreductase may negatively affect cellular apoptotic pathways stimulated by activated CB1954," wrote D.H. Palmer and coauthors.
The researchers concluded: "Finally, ...
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Source: HighBeam Research, Virus delivered nitroreductase/CB1954 acts synergistically with 5-FU...