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Heat shock protein from a non-autologous tumor used as anti-tumor vaccine.
2003 NOV 5 - (NewsRx.com & NewsRx.net) -- Heat shock protein derived from a non-autologous tumor can be used as an anti-tumor vaccine.
According to published research from Ireland, "Antigenic cross-reactivity between certain tumors has allowed the development of more widely applicable, major histocompatibility complex-disparate (allogeneic) whole-cell vaccines. This principle should also allow heat shock proteins (hsp) derived from certain tumors (and carrying cross-reactive antigens) to be used as vaccines to generate anti-tumor immunity in a range of cancer patients."
"Here, hsp70 derived from gp70-antigen+ B16 melanoma generated cytotoxic-T-lymphocyte-mediated immune protection in BALB/c mice against challenge with gp70-antigen+ CT26 colorectal tumor cells," reported David G. Casey at the National University of Ireland and colleagues throughout the U.K. "Using ovalbumin as a model tumor antigen, it is shown that hsp70 enhances peptide re-presentation by dendritic cells via class I over ...
- Hazardous effects of effluent from the chrome plating industry: 70 kDa heat...
- Magazine article from: Environmental Health Perspectives Mukhopadhyay, Indranil Saxena, Daya Krishna Chowdhuri, Debapratim Kar December 1, 2003 700+ words
...concurrent with the expression pattern of the heat shock protein 70 gene (hsp70), both in larval tissues...structure and function. Among the different heat shock proteins, the stress-inducible heat shock protein 70 (Hsp70) family is the most conserved...
- New U.S. composition patent firmly solidifies Stressgen's position in heat...
- Press release article from: PR Newswire January 15, 2002 700+ words
...fusion proteins comprised of a heat shock protein fused to any antigen. Further...our position in the field of heat shock protein fusions. The pre-GATT 17...technology for developing multiple heat shock protein fusions will remain proprietary...
- Mojave Therapeutics Announces Publication on the Identification Of an Important...
- Press release article from: PR Newswire September 30, 2002 700+ words
...leader in the development of heat shock protein-based immunotherapies, announced...ways of utilizing existing heat shock protein-based vaccines as well as...increasing the effectiveness of heat shock protein vaccines and the development...
- High-throughput screening detects heat-shock protein 90 ATPase inhibitors.
- Newspaper article from: Biotech Week June 23, 2004 700+ words
...throughput screening detects heat-shock protein 90 ATPase inhibitors. "The molecular chaperone heat-shock protein 90 (HSP90) plays a key role...screening assay for inhibitors of heat-shock protein 90 ATPase activity. Anal...
- Stressgen obtains new European patent for heat shock protein fusions.(European...
- Newspaper article from: BIOTECH Patent News January 1, 2002 700+ words
...fusion proteins comprised of heat shock proteins fused to antigens...0900). Using this patented heat shock protein 'fusion' technology, Stressgen...patent received this month on our heat shock protein 'fusion' technology," said...
- Stressgen announces issuance of U.S. patent solidifying its heat shock...
- Press release article from: PR Newswire January 4, 2002 700+ words
...our technology for developing heat shock protein fusions to treat viral diseases...market a compound such as our heat shock protein fusion candidate, HspE7...research studies to evaluate its heat shock protein 'fusion' technology in the...
- Upregulated heat shock protein 70 protects against tumor growth in mice.
- Newspaper article from: Cancer Vaccine Week May 17, 2004 700+ words
...NewsRx.net) -- Upregulated heat shock protein 70 protects against tumor growth in mice. "Although heat-shock protein 70 (Hsp70) has been considered...Cancer (Forced expression of heat-shock protein 70 increases the secretion...
- Stressgen granted United States patent covering heat shock protein HspE7.
- Newspaper article from: BIOTECH Patent News February 1, 2003 700+ words
...HPV) antigen fused to a heat shock protein (Hsp), as well as DNA encoding...fuse, or covalently link, a heat shock protein with a protein antigen to create...antigen. HspE7 is a fusion of a heat shock protein and the E7 protein from HPV...
Source: HighBeam Research, Heat shock protein from a non-autologous tumor used as anti-tumor...