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Study evaluates "rabbit fever" as part of biodefense research plan.

Vaccine Weekly

| October 08, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Since September 11, rabbits have taken on a whole new meaning for biodefense researchers at the University of Missouri-Columbia, who are trying to unravel the science behind rabbit fever, also known as tularemia, a deadly infectious disease that the U.S. government has identified as a potential biological weapon.

"We have to stay ahead of the threat, so we're working to discover a treatment for people who have been infected with rabbit fever," said Tom Reilly, an assistant professor of veterinary pathobiology in the Veterinary Medicine Diagnostic Laboratory. "While the tularemia strain that is usually found in nature can be treated with antibiotics, we are concerned that there could be strains resistant to that type of treatment."

Tularemia is classified as an intracellular pathogen, an organism that seeks to get inside the body's cells before doing any damage. Typically, once a foreign organism enters the body, the body's immune response acts by engulfing the organism inside various cells. This triggers a mechanism known as the respiratory burst that destroys the foreign organism. However, when this same process is activated with tularemia, the disease shuts down the respiratory burst mechanism and multiplies within the body.

"We believe that a specific enzyme that tularemia carries is ...

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Source: HighBeam Research, Study evaluates "rabbit fever" as part of biodefense research plan.

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