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IL-4 exerts differential effects in peptide-induced autoimmunity.
2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Interleukin (IL)-4 exerts differential effects in peptide-induced autoimmunity.
According to recent research published in the journal Clinical Immunology, "BALB/c mice immunized with multimeric DWEYSVWLSN develop IgG1 anti-DNA antibodies and glomerular immunoglobulin deposits, leading us to investigate the role of IL-4 in this model of antigen-induced lupus."
"Splenocytes from DWEYSVWLSN immunized mice secreted IL-4 but not gamma-interferon," reported Bisram Deocharan and collaborators at Albert Einstein College of Medicine and Winthrop University Hospital in the United States. "Following peptide immunization, IgG1 anti-peptide and anti-DNA antibodies were significantly higher in IL-4 wild type mice, while IgM and IgG3 anti-DNA levels were significantly higher in IL-4 knockout mice. Titers of IgG anti-laminin and anti-histone, but not anti-Sm/RNP and anti-cardiolipin antibodies, were significantly higher in the IL-4 wild type group. Glomerular immunoglobulin deposition was substantially decreased in IL-4 knockout mice."
"We conclude that while IL-4 does not materially affect the ...
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Source: HighBeam Research, IL-4 exerts differential effects in peptide-induced autoimmunity.