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New generation of cell culture assay for smallpox vaccine potency developed.
2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Researchers have developed a new generation of cell culture assay for smallpox vaccine potency.
According to a study from France, "The potency of smallpox vaccines produced in the 1970s was tested by titration onto chorioallantoic membranes of fertilized hen eggs (CAM assay). The potency specification commonly approved for these vaccines was a titer above 10[superscript]8 pock-forming units per milliliter."
"We developed and validated a cell culture titration assay to have a more reliable potency test," reported Isabelle Leparc-Goffart at the Agence Francaise de Securite Sanitaire des Produits de Sante and collaborators in France. "The cell titration assay and the CAM assay were tested in parallel on 34 first-generation smallpox vaccine lots. These allowed us to demonstrate that a correlation does exist between the two titration techniques and to determine a new in-house specification for the cell titration method. This in vitro potency assay will allow us to test ...
- Should cell culture smallpox vaccine be offered to general population?
- News wire article from: Bioterrorism Week March 17, 2003 700+ words
...net) -- The new cell culture smallpox vaccine should be offered to...believe that that the new cell culture smallpox vaccine should NOT be offered...Virology (The new cell culture smallpox vaccine should be offered to...
- Clonal vaccinia virus grown in cell culture as a new smallpox vaccine.
- Newspaper article from: Virus Weekly October 21, 2003 700+ words
...virus has been grown in cell culture as a new smallpox vaccine. According to published...To develop a modern smallpox vaccine, we have adapted vaccinia...vaccinia virus grown in cell culture as a new smallpox vaccine. Nature Med, 2003...
- Aventis Pasteur Donates Approximately 75 to 90 Million Doses of Smallpox...
- Press release article from: PR Newswire March 29, 2002 700+ words
...that it will donate its smallpox vaccine inventory to the U.S...started to produce a new cell culture-based smallpox vaccine in Europe, which it anticipates...development of an improved smallpox vaccine based on its proprietary...
- Aventis Pasteur Donates Approximately 75 to 90 Million Doses of Smallpox...
- Press release article from: Business Wire March 29, 2002 700+ words
...that it will donate its smallpox vaccine inventory to the U.S...started to produce a new cell culture-based smallpox vaccine in Europe, which it anticipates...development of an improved smallpox vaccine based on its proprietary...
- Study Describes Advantages of Acambis' Clonal Smallpox Vaccine.
- Press release article from: PR Newswire August 19, 2003 700+ words
A new smallpox vaccine developed by...made in modern cell-culture system, is...stockpile of smallpox vaccine for use in...using modern cell-culture methods indicates...Acambis' new smallpox vaccine represents...
- Study describes advantages of Acambis' clonal smallpox vaccine.
- Press release article from: PR Newswire August 19, 2003 700+ words
...A new smallpox vaccine developed by...made in modern cell-culture system, is...stockpile of smallpox vaccine for use in...using modern cell-culture methods indicates...Acambis' new smallpox vaccine represents...
- NEW SMALLPOX VACCINE? ISN'T UNTHINKABLE LONG GONE? MICE, MONKEYS, HUMAN...
- Magazine article from: BIOWORLD Today Leff, David N. September 11, 2003 700+ words
...trials of a new- generation smallpox vaccine. The Cambridge, Mass...vaccinia virus grown in cell culture as a new smallpox vaccine." "The first point of...larger national stockpile of smallpox vaccine for the purpose of countering...
- DynCorp enters phase I smallpox vaccine clinical trial.
- Newspaper article from: Drug Week May 31, 2002 700+ words
...volunteers for a new smallpox vaccine. DVC's trial...compares a smallpox vaccine, developed...large-scale cell culture technology...large-scale cell culture technology...specific smallpox vaccine experience...
