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2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Researchers have published a comparison of the Bordetella pertussis and B. parapertussis isolates circulating in Saint Petersburg between 1998 and 2000 with Russian vaccine strains in the Journal of Clinical Microbiology.
According to recent research from Russia and France, "We analyzed the Bordetella pertussis and Bordetella parapertussis isolates circulating in Saint Petersburg that were collected between 1998 and 2000 and compared them with isolates collected 40 years ago and Russian vaccine strains."
"The analysis involved serotyping, pulsed-field gel electrophoresis of chromosomal DNA after digestion with XbaI and SpeI, and sequencing of the ptxS1 and pm genes, which encode the S1 subunit of the pertussis toxin and the major adhesin pertactin, respectively," reported Natacha Kourova and collaborators at the Pasteur Institute of Epidemiology and Microbiology and the L. A. Tarassevich State Control and Standardization Institute in Russia and the Institut Pasteur in France. "The Russian isolates were classified in five of the six pulsed-field gel electrophoresis groups identified in other European countries."
The investigators found, "The B. pertussis isolates currently circulating in Saint Petersburg differed from the Russian whole-cell vaccine strains and the isolates collected in the prevaccine era. However, their repartition in the ...