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Haemophilus influenzae antibodies present in vaccinated infants.
2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Antibodies to Haemophilus influenzae type b polysaccharide canonical variable regions are present in vaccinated infants.
According to recent research published in the journal Clinical Immunology, "A structurally, conserved antibody combining site, encoded by the IGH V3-23 and kappa A2 variable (V) region gene segments, predominates the adult immune response to the Haemophilus influenzae type b (Hib) capsular polysaccharide (PS). This site has been elevated to canonical status based upon its relative molecular uniformity and prevalence in adults. To date, no studies have examined the primary structure of Hib PS-specific antibodies in young infants, who are the primary targets of Hib vaccination."
"In this study we show that canonical Hib PS-specific heavy (H) and light (L) chain V regions are present in four-month-old infants following two vaccinations with Hib PS-protein conjugates," reported Alexander H. Lucas and collaborators at Children's Hospital Oakland Research Institute and Berkeley Pediatric Medical Group in California. "The infant V regions contain sequence polymorphisms that resemble those found in adult antibodies, as well as polymorphisms at position 95a of the A2 L chain not previously observed in adults. In vitro studies of Fab fragments and recombinant IgG2 ...
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Source: HighBeam Research, Haemophilus influenzae antibodies present in vaccinated infants.