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Systemic treatment for advanced melanoma reviewed.
2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Researchers have reviewed systemic treatments for advanced melanoma in a recent issue of the journal Onkologie.
According to recent research from Germany, "Malignant melanoma is a tumor of increasing incidence. Patients with early diagnosed and surgically excised primary tumors have a high probability to be completely cured. In contrast, the prognosis of patients with distant organ metastases is still extremely poor despite a variety of therapeutical efforts that have been evaluated in numerous clinical trials."
"Cytotoxic treatment using single agents as well as polychemotherapy revealed only temporary clinical responses but no improvement of patients' overall survival," reported Selma Ugurel at the University Hospital of Mannheim and D. Schadendorf at the University of Heidelberg. "Likewise, therapy regimens combining cytostatics with cytokines showed no substantial benefit compared to cytostatics alone. Due to these disappointing results, recent research strategies focused on the elucidation of the mechanisms responsible for the complex therapy resistance of melanoma. New treatment concepts have been developed to overcome some of ...
- Genta Announces a New Controlled Phase 3 Trial of Genasense(R) in Patients with...
- Press release article from: M2 Presswire April 18, 2007 700+ words
...Genasense(R) in Patients with Advanced Melanoma(C)1994-2007 M2 COMMUNICATIONS...sodium) Injection, in patients with advanced melanoma. The Company has sought scientific...randomized study in patients with advanced melanoma," commented Dr. Agop Y. Bedikian...
- FDA Advisory Committee Reviews Genasense(TM) for Use in Advanced Melanoma.
- Press release article from: PR Newswire May 3, 2004 700+ words
...what it represents to patients with advanced melanoma," said Dr. Raymond P. Warrell...the appropriate next steps." "Advanced melanoma represents a significant unmet medical...plus dacarbazine in patients with advanced melanoma. The study -- the largest randomized...
- Genta Announces New Phase 3 Trial of Genasense(R) in Patients with Advanced...
- Press release article from: PR Newswire April 18, 2007 700+ words
...sodium) Injection, in patients with advanced melanoma. The Company has sought scientific...randomized study in patients with advanced melanoma," commented Dr. Agop Y. Bedikian...commitment to patients afflicted with advanced melanoma," said Dr. Raymond P. Warrell...
- Genta and Aventis Announce Genasense(TM) Expanded Access Program for Patients...
- Press release article from: PR Newswire April 20, 2004 700+ words
...eligible patients in the U.S. with advanced melanoma who have not previously received...potential approval for the treatment of advanced melanoma. Expanded access programs are designed...randomized trial ever conducted for advanced melanoma. In this phase 3 trial, 771 patients...
- Genasense(R) Data in Patients with Advanced Melanoma to be Featured at 4th...
- Press release article from: PR Newswire October 24, 2007 700+ words
...oblimersen) in patients with advanced melanoma will be featured at the 4th International...oblimersen-dacarbazine regimen in advanced melanoma: PFS difference is not explained...chemotherapy-naive patients with advanced melanoma and low LDH. Presenter: A. Bedikian...
- Companies announce Genasense EAP for those with advanced melanoma.
- Newspaper article from: Drug Week May 21, 2004 700+ words
...eligible patients in the U.S. with advanced melanoma who have not previously received...potential approval for the treatment of advanced melanoma. EAPs are designed to make investigational...randomized trial ever conducted for advanced melanoma. In this phase III trial, 771 ...
- New Publication Confirms Critical Link of LDH Biomarker in Genasense[R] Trials...
- Press release article from: Business Wire July 14, 2009 700+ words
...overall survival in patients with advanced melanoma. The biomarker, a tumor-derived...3 trial of Genasense([R]) in advanced melanoma, known as AGENDA, specified low...compared outcomes of patients with advanced melanoma who were treated using standard chemotherapy...
- Genta and Aventis Announce FDA Acceptance and Priority Review of New Drug...
- Press release article from: PR Newswire February 6, 2004 700+ words
...for the treatment of patients with advanced melanoma who have not previously received...first new drug for patients with advanced melanoma in almost 30 years," said Loretta...treatment option for patients with advanced melanoma." "The FDA's decision to grant...