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Phase II study demonstrates vaccine effectiveness in half of patients.
2003 OCT 8 - (NewsRx.com & NewsRx.net) -- A Phase II clinical study reports that administration of a prototype vaccine, developed by Therion Biologics Corp., administered in combination with interleukin-2 (IL-2), generated objective tumor response in 6 of 12 (50%) treated patients with metastatic melanoma, 3 of whom remained free of disease at 16, 18 and 26 months, respectively.
Conducted by the U.S. National Cancer Institute (NCI) under the direction of Steven A. Rosenberg, MD, PhD, NCI chief of surgery, the study, "Recombinant fowlpox viruses encoding the anchor-modified gp100 melanoma antigen can generate antitumor immune responses in patients with metastatic melanoma", was published in Clinical Cancer Research (2003;9(8):2973-80).
One arm of the study evaluated a fowlpox-based vaccine encoding a modified peptide of the gp100 melanoma-melanocyte antigen. The vaccine was administered to 23 patients with metastatic melanoma. Patients were prospectively randomized to ...
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