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Multiple T cell subsets control Francisella tularensis growth.
2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Multiple T cell subsets control Francisella tularensis live vaccine strain intracellular growth without stimulation through macrophage interferon gamma receptors.
According to a study from the United States, "A variety of data suggest that in vivo production of interferon (IFN)-gamma is necessary, but not sufficient, for expression of secondary protective immunity against intracellular pathogens. To discover specific IFN-gamma-independent T cell mediated mechanisms, we took advantage of an in vitro culture system that models in vivo immune responses to the intracellular bacterium Francisclla tularensis live vaccine strain (LVS)."
"LVS-immune lymphocytes specifically controlled 99% of the growth of LVS in wild-type murine bone marrow-derived macrophages," reported Siobhan C. Cowley and Karen L. Elkins at the Food and Drug Administration. "Surprisingly, LVS-immune lymphocytes also inhibited LVS intracellular growth by as much as 95% in macrophages derived from IFN-gamma receptor knockout (IFN-gamma-P KO) mice. CD8+ T cells, and to a lesser degree CD4+ T cells, controlled LVS intracellular growth in both wild-type and IFN-gamma-R KO macrophages. Further, a unique population of Thy1[superscript]+alphabeta[superscript]+CD4[superscript]-CD4[superscript]-CD8[superscript]- cells that was previously suggested to operate during secondary immunity to LVS in vivo strongly controlled LVS intracellular growth ...
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Source: HighBeam Research, Multiple T cell subsets control Francisella tularensis growth.