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Novel vaccine strategies reported with Streptococcus pneumoniae antigens.

Vaccine Weekly

| October 08, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 OCT 8 - (NewsRx.com & NewsRx.net) -- Novel vaccine strategies with protein antigens of Streptococcus pneumoniae have been reported recently.

According to a study from the United States, "Infections caused by Streptococcus pneumoniae (pneumococcus) are a major cause of mortality throughout the world. This organism is primarily a commensal in the upper respiratory tract of humans, but can cause pneumonia in high-risk persons and disseminate from the lungs by invasion of the bloodstream."

"Currently, prevention of pneumococcal infections is by immunization with vaccines which contain capsular polysaccharides from the most common serotypes causing invasive disease," said Edwin Swiatlo and Daphne Ware at the University of Mississippi. "However, there are more than 90 antigenically distinct serotypes and there is concern that serotypes not included in the vaccines may become more prevalent in the face of continued use of polysaccharide vaccines. Also, certain high-risk groups have poor immunological responses to some of the polysaccharides in the vaccine formulations."

"Protein antigens that are conserved across all capsular serotypes would induce ...

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Source: HighBeam Research, Novel vaccine strategies reported with Streptococcus pneumoniae...

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